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Abstract：
Background Knee osteoarthritis (KOA) is the most typical cause of knee pain and impairment worldwide. It is typified by slow and progressive degeneration of the articular cartilage of the knee joint. Although KOA is being managed with a variety of therapies, the comparison of the effectiveness of different intra-articular injections in KOA treatment in Pakistan is still not thoroughly investigated. Therefore, the purpose of this current study is to compare the efficacy of intra-articular administration of platelet-rich plasma (PRP) and corticosteroids (CSs) in the treatment of KOA. Methods This prospective comparative study was performed among one hundred patients diagnosed with KOA in Benazir Bhutto Hospital, Rawalpindi, for one year from April 2022 to March 2023. Specified inclusion and exclusion criteria were employed for patient enrollment. Patients were divided into two equal groups through simple random sampling. Group A patients received an intra-articular injection of PRP solution whereas group B patients received an intra-articular injection of CSs. Informed consent and ethical approval were also acquired prior to data collection. A self-designed proforma based on interviews was used to collect data. The data analysis in Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Version 25.0, Armonk, NY) was carried out via descriptive statistics and an independent t-test. Results Women (N=71, 71%) had a higher prevalence of KOA than men (N=29, 29%). The means of study variables like age, Visual Analog Scale (VAS) score, and Western Ontario and McMaster Universities (WOMAC) score were 56.10 ± 8.70 years, 8.08 ± 1.6, and 70.08 ± 8.76 respectively. The frequency of KOA on the right side was 62% (N=62) while it was 38% (N=38) on the left side. In the study population, 69% (N=69) patients had grade II KOA, and 31% (N=31) patients had grade III KOA. At the first-month, second-month, and third-month follow-up visits, there were statistically significant differences in the mean scores of the WOMAC and VAS between the study groups. However, at the first-month follow-up visit, mean scores of VAS and WOMAC were lower in group B than in group A while these were lower in group A as compared to group B, at the second-month and third-month follow-up appointments. Conclusions Intra-articular infiltration of both PRP and CSs was efficacious in the treatment of KOA-related pain and functional limitations; however, overall improvement in the PRP group was higher than CS group.
摘要：
背景膝关节骨性关节炎(KOA)是世界范围内膝关节疼痛和损伤的最典型原因。以膝关节的关节软骨的缓慢和进行性变性为代表。尽管KOA正在通过各种疗法进行管理，在巴基斯坦,不同关节腔内注射治疗KOA的效果比较仍未得到彻底研究.因此,本研究的目的是比较富血小板血浆(PRP)和糖皮质激素(CSs)关节内给药治疗KOA的疗效.方法对100例贝娜齐尔·布托医院诊断为KOA的患者进行前瞻性对比研究。拉瓦尔品第,为期一年，从2022年4月到2023年3月。指定的纳入和排除标准用于患者登记。通过简单随机抽样将患者分为两组。A组患者接受关节内注射PRP溶液，而B组患者接受关节内注射CSs。在数据收集之前还获得了知情同意和伦理批准。使用基于访谈的自行设计的形式来收集数据。社会科学统计软件包中的数据分析（IBMSPSSStatisticsforWindows，IBM公司,版本25.0,Armonk,NY)通过描述性统计和独立t检验进行。结果女性（N=71，71％）的KOA患病率高于男性（N=29，29％）。研究变量的手段，如年龄，视觉模拟量表(VAS)评分,西安大略和麦克马斯特大学(WOMAC)得分为56.10±8.70岁，分别为8.08±1.6和70.08±8.76。右侧KOA的频率为62%(N=62),而左侧为38%(N=38)。在研究人群中，69%(N=69)患者患有II级KOA，31%(N=31)的患者患有III级KOA。在第一个月，第二个月，以及第三个月的随访,研究组之间WOMAC和VAS的平均得分差异有统计学意义.然而,在第一个月的随访中，B组的平均VAS和WOMAC评分低于A组，而A组的平均VAS和WOMAC评分低于B组，在第二个月和第三个月的后续预约。结论PRP和CSs关节内浸润治疗KOA相关疼痛和功能受限均有效;PRP组的总体改善高于CS组.
