PDF(Pubmed)
Abstract：
Sevoflurane is one of the most commonly used volatile anesthetics in clinical practice and is often used in pediatric anesthesia and intraoperative maintenance. Microglia exist in the central nervous system and are innate immune cells in the central nervous system. Under external stimulation, microglia are divided into two phenotypes: proinflammatory (M1 type) and anti-inflammatory (M2 type), maintaining the stability of the central nervous system through induction, housekeeping, and defense functions. Sevoflurane can activate microglia, increase the expression of inflammatory factors through various inflammatory signaling pathways, release inflammatory mediators to cause oxidative stress, damage nerve tissues, and eventually develop into neurodegenerative diseases. In this article, the relationship between sevoflurane anesthesia and microglia inflammation expression and the occurrence of neurodegenerative diseases is reviewed as follows.
摘要：
七氟醚是临床上最常用的挥发性麻醉药之一，常用于小儿麻醉和术中维持。小胶质细胞存在于中枢神经系统中,是中枢神经系统中的固有免疫细胞。在外界刺激下,小胶质细胞分为两种表型：促炎（M1型）和抗炎（M2型），通过诱导维持中枢神经系统的稳定，家政服务,和防御功能。七氟醚可以激活小胶质细胞，通过各种炎症信号通路增加炎症因子的表达,释放炎症介质引起氧化应激，损伤神经组织，并最终发展为神经退行性疾病。在这篇文章中,现将七氟烷麻醉与小胶质细胞炎症表达及神经退行性疾病发生的关系综述如下。
