PDF(Pubmed)
Abstract：
In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs. Despite the significance of natural product drugs in the field of oral medications, there is a lack of research on the regulatory interplay between gut microbiome-derived hydrolases and these drugs. This review delves into the interaction between intestinal microbiome-derived hydrolases and natural product drugs metabolism from three key perspectives. Firstly, it examines the impact of glycoside hydrolases, amide hydrolases, carboxylesterase, bile salt hydrolases, and epoxide hydrolase on the structure of natural products. Secondly, it explores how natural product drugs influence microbiome-derived hydrolases. Lastly, it analyzes the impact of interactions between hydrolases and natural products on disease development and the challenges in developing microbial-derived enzymes. The overarching goal of this review is to lay a solid theoretical foundation for the advancement of research and development in new natural product drugs and personalized treatment.
摘要：
近年来,人们对研究与口服药物代谢相关的肠道微生物组来源的水解酶越来越感兴趣，特别是专注于天然产物药物。尽管天然产物药物在口服药物领域的重要性，缺乏关于肠道微生物组来源的水解酶与这些药物之间的调节相互作用的研究.本文从三个关键角度探讨了肠道微生物组来源的水解酶与天然产物药物代谢之间的相互作用。首先,它检查了糖苷水解酶的影响，酰胺水解酶，羧酸酯酶，胆汁盐水解酶，和环氧化物水解酶对天然产物结构的影响。其次,它探讨了天然产物药物如何影响微生物组衍生的水解酶。最后,它分析了水解酶和天然产物之间的相互作用对疾病发展的影响，以及开发微生物衍生酶的挑战。本综述的总体目标是为推进新型天然产物药物的研发和个性化治疗奠定坚实的理论基础。
