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Abstract：
O-GlcNAcylation, as a post-translational modification, can modulate cellular activities such as kinase activity, transcription-translation, protein degradation, and insulin signaling by affecting the function of the protein substrate, including cellular localization of proteins, protein stability, and protein/protein interactions. Accumulating evidence suggests that dysregulation of O-GlcNAcylation is associated with disease progression such as cancer, neurodegeneration, and diabetes. Recent studies suggest that O-GlcNAcylation is also involved in the regulation of osteoblast, osteoclast and chondrocyte differentiation, which is closely related to the initiation and development of bone metabolic diseases such as osteoporosis, arthritis and osteosarcoma. However, the potential mechanisms by which O-GlcNAcylation regulates bone metabolism are not fully understood. In this paper, the literature related to the regulation of bone metabolism by O-GlcNAcylation was summarized to provide new potential therapeutic strategies for the treatment of orthopedic diseases such as arthritis and osteoporosis.
摘要：
O-GlcNAcylation,作为翻译后修饰，可以调节细胞活性，如激酶活性，转录-翻译，蛋白质降解，和胰岛素信号通过影响蛋白质底物的功能，包括蛋白质的细胞定位，蛋白质稳定性，和蛋白质/蛋白质相互作用。越来越多的证据表明，O-GlcNAcylation的失调与癌症等疾病进展有关。神经变性,和糖尿病。最近的研究表明，O-GlcNAcylation也参与了成骨细胞的调节，破骨细胞和软骨细胞分化，与骨质疏松等骨代谢性疾病的发生发展密切相关,关节炎和骨肉瘤.然而,O-GlcNAcylation调节骨代谢的潜在机制尚不完全清楚。在本文中,综述了O-GlcNAcylation对骨代谢调控的相关文献,以期为关节炎和骨质疏松等骨科疾病的治疗提供新的潜在治疗策略。
