PDF(Pubmed)
Abstract：
UNASSIGNED: The COVID-19 pandemic related to SARS-CoV-2 virus was responsible for global pandemic. The severe form of the disease was linked to excessive activation of immune pathways together with a systemic cytokine storm response and thrombotic venous or arterial complications. Factors predicting severe outcomes including venous and/or pulmonary thrombosis (VT) and death were identified, but the prognostic role of their combination was not addressed extensively.
UNASSIGNED: We investigated the role of prognostic factors from the coagulation or inflammatory pathways to better understand the outcome of the disease.
UNASSIGNED: For this, we prospectively studied 167 SARS-CoV-2-positive patients from admission in intensive care units (ICU) or emergency departments from four academic hospitals over a 14-month period. Besides standard biology, we assessed serum concentrations of inflammatory markers, coagulation factors and peripheral blood cells immunophenotyping.
UNASSIGNED: Thirty-nine patients (23.3%) developed VT and 30 patients (18%) died. By univariate analysis, C-reactive protein (CRP) level > 150 mg/L, interleukin-6 (IL-6) ≥ 20 pg/mL, D-dimers > 1,500 μg/L, ADAMTS13 activity ≤ 50%, Von.
UNASSIGNED: A combination of coagulation and inflammatory markers can refine the prognostication of severe outcome in COVID-19, and could be useful for the initial evaluation of other types of viral infection.
UNASSIGNED: We investigated the role of prognostic factors from the coagulation or inflammatory pathways to better understand the outcome of the disease.
UNASSIGNED: For this, we prospectively studied 167 SARS-CoV-2-positive patients from admission in intensive care units (ICU) or emergency departments from four academic hospitals over a 14-month period. Besides standard biology, we assessed serum concentrations of inflammatory markers, coagulation factors and peripheral blood cells immunophenotyping.
UNASSIGNED: Thirty-nine patients (23.3%) developed VT and 30 patients (18%) died. By univariate analysis, C-reactive protein (CRP) level > 150 mg/L, interleukin-6 (IL-6) ≥ 20 pg/mL, D-dimers > 1,500 μg/L, ADAMTS13 activity ≤ 50%, Von.
UNASSIGNED: A combination of coagulation and inflammatory markers can refine the prognostication of severe outcome in COVID-19, and could be useful for the initial evaluation of other types of viral infection.
摘要：
■与SARS-CoV-2病毒有关的COVID-19大流行是全球大流行的原因。该疾病的严重形式与免疫途径的过度激活以及全身性细胞因子风暴反应和血栓性静脉或动脉并发症有关。确定了预测严重结局的因素，包括静脉和/或肺血栓形成（VT）和死亡，但两者联合的预后作用并未得到广泛讨论.
■我们研究了凝血或炎症途径的预后因素的作用，以更好地了解疾病的结果。
■为此，我们在14个月的时间内,前瞻性研究了来自4家学术医院的重症监护病房(ICU)或急诊科的167例SARS-CoV-2阳性患者.除了标准生物学,我们评估了血清炎症标志物的浓度，凝血因子和外周血细胞免疫分型。
■39例患者（23.3%）发生室性心动过速，30例患者（18%）死亡。通过单变量分析，C反应蛋白(CRP)水平>150mg/L,白细胞介素-6（IL-6）≥20pg/mL，D-二聚体>1,500μg/L，ADAMTS13活性≤50%,冯
■凝血和炎症标志物的组合可以改善COVID-19严重结局的预测，并可能有助于其他类型病毒感染的初步评估。
■我们研究了凝血或炎症途径的预后因素的作用，以更好地了解疾病的结果。
■为此，我们在14个月的时间内,前瞻性研究了来自4家学术医院的重症监护病房(ICU)或急诊科的167例SARS-CoV-2阳性患者.除了标准生物学,我们评估了血清炎症标志物的浓度，凝血因子和外周血细胞免疫分型。
■39例患者（23.3%）发生室性心动过速，30例患者（18%）死亡。通过单变量分析，C反应蛋白(CRP)水平>150mg/L,白细胞介素-6（IL-6）≥20pg/mL，D-二聚体>1,500μg/L，ADAMTS13活性≤50%,冯
■凝血和炎症标志物的组合可以改善COVID-19严重结局的预测，并可能有助于其他类型病毒感染的初步评估。
