UNASSIGNED: We investigated the role of prognostic factors from the coagulation or inflammatory pathways to better understand the outcome of the disease.
UNASSIGNED: For this, we prospectively studied 167 SARS-CoV-2-positive patients from admission in intensive care units (ICU) or emergency departments from four academic hospitals over a 14-month period. Besides standard biology, we assessed serum concentrations of inflammatory markers, coagulation factors and peripheral blood cells immunophenotyping.
UNASSIGNED: Thirty-nine patients (23.3%) developed VT and 30 patients (18%) died. By univariate analysis, C-reactive protein (CRP) level > 150 mg/L, interleukin-6 (IL-6) ≥ 20 pg/mL, D-dimers > 1,500 μg/L, ADAMTS13 activity ≤ 50%, Von.
UNASSIGNED: A combination of coagulation and inflammatory markers can refine the prognostication of severe outcome in COVID-19, and could be useful for the initial evaluation of other types of viral infection.
■我们研究了凝血或炎症途径的预后因素的作用,以更好地了解疾病的结果。
■为此,我们在14个月的时间内,前瞻性研究了来自4家学术医院的重症监护病房(ICU)或急诊科的167例SARS-CoV-2阳性患者.除了标准生物学,我们评估了血清炎症标志物的浓度,凝血因子和外周血细胞免疫分型。
■39例患者(23.3%)发生室性心动过速,30例患者(18%)死亡。通过单变量分析,C反应蛋白(CRP)水平>150mg/L,白细胞介素-6(IL-6)≥20pg/mL,D-二聚体>1,500μg/L,ADAMTS13活性≤50%,冯
■凝血和炎症标志物的组合可以改善COVID-19严重结局的预测,并可能有助于其他类型病毒感染的初步评估。