PDF(Pubmed)
Abstract：
This study sought to compare in vivo sex differences in either a Th1-dominant CTL response or a Tfh-mediated lupus-like antibody response using the parent-into F1 murine model of acute or chronic GVHD respectively. In acute GVHD we observed no significant sex differences in the hierarchy of donor CD8 CTL elimination of splenocyte subsets. B cells were the most sensitive to elimination in both sexes; however, the male response was significantly stronger. Sex differences in chronic GVHD were more widespread; females exhibited significantly greater numbers of total splenocytes and host CD4 Tfh cells, B cells and CD8 T cells consistent with reports of greater female autoantibody production in this model. The more potent male CTL response in acute GVHD conflicts with reports of greater female CTL responses following infections or vaccines and may reflect the absence of exogenous innate immune stimuli in this model.
摘要：
这项研究试图分别使用急性或慢性GVHD的亲本F1鼠模型比较Th1显性CTL反应或Tfh介导的狼疮样抗体反应的体内性别差异。在急性GVHD中，我们观察到供体CD8CTL消除脾细胞亚群的层次结构没有显着性别差异。在两性中，B细胞对消除最敏感；然而，男性反应明显更强。慢性GVHD的性别差异更为广泛；女性表现出明显更多的总脾细胞和宿主CD4Tfh细胞，B细胞和CD8T细胞与该模型中更多女性自身抗体产生的报道一致。急性GVHD中更有效的男性CTL反应与感染或疫苗后更大的女性CTL反应的报道相冲突，并且可能反映了该模型中缺乏外源性先天免疫刺激。
