PDF(Pubmed)
Abstract：
Immune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production. TLRs share common downstream signaling pathways with other receptors. The crosstalk revolving around TLRs is rather significant and complex, underscoring the intricate nature of immune system. The profiles of produced cytokines and chemokines via TLRs can be affected by other receptors. Integrins are critical heterodimeric adhesion molecules expressed on many different cells. There are studies describing synergetic or inhibitory interplay between TLRs and integrins. Thus, we reviewed the crosstalk between TLRs and integrins. Understanding the nature of the crosstalk could allow us to modulate TLR functions via integrins.
摘要：
免疫系统在病原体和抗原水平上识别入侵的微生物。Toll样受体(TLRs)在抵抗病原体的一线防御中起关键作用。TLR的主要功能包括细胞因子和趋化因子的产生。TLR与其他受体共享共同的下游信号通路。围绕TLR的串扰是相当重要和复杂的，强调免疫系统的复杂性。通过TLR产生的细胞因子和趋化因子的谱可受到其他受体的影响。整合素是在许多不同细胞上表达的关键异二聚体粘附分子。有研究描述了TLR和整合素之间的协同或抑制性相互作用。因此，我们回顾了TLRs和整合素之间的串扰。了解串扰的性质可以允许我们通过整合素来调制TLR功能。
