PDF(Pubmed)
Abstract：
UNASSIGNED: Despite advancements in the management of patients with sickle cell disease (SCD), the involvement of the cardiovascular system in these patients remains a significant concern. Cardiovascular manifestations of SCD are well-documented, with electrocardiography (ECG) serving as a valuable diagnostic tool. Studies have reported a high rate of critical ECG findings in patients with SCD that warrants consideration when managing these patients, indicating the need for proactive cardiac screening and management strategies in this patient population. This study aims to systematically review the literature to identify sociodemographic, clinical, and paraclinical factors associated with ECG abnormalities in patients with SCD.
UNASSIGNED: A comprehensive search strategy will be employed across multiple online databases, including PubMed, Embase, Scopus, Web of Science, and Google Scholar, for published and gray literature. Eligible studies will include original articles reporting associations between sociodemographic, clinical, and paraclinical variables and a spectrum of ECG findings in patients with SCD. Independent reviewers will conduct the screening, quality assessment, and data extraction. Quantitative analyses will be performed under a random-effect model using Comprehensive Meta-Analysis software, with subgroup analyses based on SCD status, sickle hemoglobinopathy form, and age group.
UNASSIGNED: A comprehensive search strategy will be employed across multiple online databases, including PubMed, Embase, Scopus, Web of Science, and Google Scholar, for published and gray literature. Eligible studies will include original articles reporting associations between sociodemographic, clinical, and paraclinical variables and a spectrum of ECG findings in patients with SCD. Independent reviewers will conduct the screening, quality assessment, and data extraction. Quantitative analyses will be performed under a random-effect model using Comprehensive Meta-Analysis software, with subgroup analyses based on SCD status, sickle hemoglobinopathy form, and age group.
摘要：
■尽管镰状细胞病（SCD）患者的管理取得了进展，这些患者的心血管系统受累仍然是一个重要问题.SCD的心血管表现有据可查，心电图（ECG）作为有价值的诊断工具。研究报告了SCD患者的严重心电图发现率很高，在管理这些患者时值得考虑。表明该患者人群需要前瞻性心脏筛查和管理策略.本研究旨在系统地回顾文献，以确定社会人口统计学，临床,以及与SCD患者心电图异常相关的临床旁因素。
■将在多个在线数据库中采用全面的搜索策略，包括PubMed,Embase,Scopus,WebofScience,和谷歌学者，出版和灰色文献。符合条件的研究将包括报告社会人口统计学、临床,SCD患者的临床旁变量和心电图检查结果。独立审核员将进行筛选，质量评估，和数据提取。定量分析将在随机效应模型下使用综合荟萃分析软件，使用基于SCD状态的亚组分析，镰状血红蛋白病形式，和年龄组。
■将在多个在线数据库中采用全面的搜索策略，包括PubMed,Embase,Scopus,WebofScience,和谷歌学者，出版和灰色文献。符合条件的研究将包括报告社会人口统计学、临床,SCD患者的临床旁变量和心电图检查结果。独立审核员将进行筛选，质量评估，和数据提取。定量分析将在随机效应模型下使用综合荟萃分析软件，使用基于SCD状态的亚组分析，镰状血红蛋白病形式，和年龄组。
