PDF(Pubmed)
Abstract：
UNASSIGNED: This study explored the level of nuclear factor-ƙB (NF-ƙB) in the bronchoalveolar lavage fluid (BALF) of children with severe Mycoplasma Pneumoniae pneumonia (SMPP) and the correlation between NF-ƙB, cellular immunity, and clinical characteristics.
UNASSIGNED: A total of 41 hospitalized children diagnosed with SMPP were selected and included in the SMPP group, and 13 bronchial foreign bodies (FB) without infection during the same period were included in the FB group. The NF-ƙB in the BALF of participants was detected by enzyme-linked immunosorbent assay. The correlation between NF-ƙB and laboratory findings, cellular immunity, and the clinical features in children with SMPP was analyzed. The differences in chest imaging and bronchoscopy in children with SMPP were observed.
UNASSIGNED: The levels of NF-ƙB were significantly increased in the SMPP group compared with the FB group (P < 0.001). There were correlations between different NF-ƙB pairs in the SMPP group (P < 0.01). Nuclear factor-ƙB (NF-ƙB) correlated with IL-6, the mycoplasma load in BALF, fever peak, length of hospital stay, and sputum suppository (P < 0.05). The higher the intracellular NF-ƙB level in BALF, the lower the CD3+ CD4+ value in peripheral blood (P < 0.05). Intracellular NF-ƙB and total NF-ƙB correlated with pleural effusion, pericardial effusion, and extrapulmonary complications (P < 0.05).
UNASSIGNED: NF-ƙB is involved in airway inflammation changes in children with SMPP. The higher the level of NF-ƙB in the airway, the more severe the clinical manifestations, and the longer the length of hospital stay is likely to be.
UNASSIGNED: A total of 41 hospitalized children diagnosed with SMPP were selected and included in the SMPP group, and 13 bronchial foreign bodies (FB) without infection during the same period were included in the FB group. The NF-ƙB in the BALF of participants was detected by enzyme-linked immunosorbent assay. The correlation between NF-ƙB and laboratory findings, cellular immunity, and the clinical features in children with SMPP was analyzed. The differences in chest imaging and bronchoscopy in children with SMPP were observed.
UNASSIGNED: The levels of NF-ƙB were significantly increased in the SMPP group compared with the FB group (P < 0.001). There were correlations between different NF-ƙB pairs in the SMPP group (P < 0.01). Nuclear factor-ƙB (NF-ƙB) correlated with IL-6, the mycoplasma load in BALF, fever peak, length of hospital stay, and sputum suppository (P < 0.05). The higher the intracellular NF-ƙB level in BALF, the lower the CD3+ CD4+ value in peripheral blood (P < 0.05). Intracellular NF-ƙB and total NF-ƙB correlated with pleural effusion, pericardial effusion, and extrapulmonary complications (P < 0.05).
UNASSIGNED: NF-ƙB is involved in airway inflammation changes in children with SMPP. The higher the level of NF-ƙB in the airway, the more severe the clinical manifestations, and the longer the length of hospital stay is likely to be.
摘要：
■本研究探讨了重症肺炎支原体肺炎（SMPP）患儿支气管肺泡灌洗液（BALF）中核因子B（NF-B）的水平及其与NF-B的相关性。细胞免疫,和临床特征。
■选择41例确诊为SMPP的住院儿童，并将其纳入SMPP组，13例同期未感染的支气管异物(FB)纳入FB组。通过酶联免疫吸附试验检测参与者BALF中的NF-κB。NF-B与实验室检查结果之间的相关性，细胞免疫,分析SMPP患儿的临床特点。观察SMPP患儿胸部影像学和支气管镜检查的差异。
■与FB组相比，SMPP组的NF-κB水平显着升高（P<0.001）。SMPP组不同NF-κB对之间存在相关性（P<0.01）。核因子-B（NF-toB）与IL-6，BALF中的支原体负荷相关，发烧高峰，住院时间,和痰栓(P<0.05)。BALF中细胞内NF-κB水平越高，外周血CD3+CD4+值越低(P<0.05)。细胞内NF-κB和总NF-κB与胸腔积液相关，心包积液,肺外并发症(P<0.05)。
■NF-etchB参与SMPP患儿气道炎症改变。气道中NF-κB的水平越高，临床表现越严重，住院时间越长。
■选择41例确诊为SMPP的住院儿童，并将其纳入SMPP组，13例同期未感染的支气管异物(FB)纳入FB组。通过酶联免疫吸附试验检测参与者BALF中的NF-κB。NF-B与实验室检查结果之间的相关性，细胞免疫,分析SMPP患儿的临床特点。观察SMPP患儿胸部影像学和支气管镜检查的差异。
■与FB组相比，SMPP组的NF-κB水平显着升高（P<0.001）。SMPP组不同NF-κB对之间存在相关性（P<0.01）。核因子-B（NF-toB）与IL-6，BALF中的支原体负荷相关，发烧高峰，住院时间,和痰栓(P<0.05)。BALF中细胞内NF-κB水平越高，外周血CD3+CD4+值越低(P<0.05)。细胞内NF-κB和总NF-κB与胸腔积液相关，心包积液,肺外并发症(P<0.05)。
■NF-etchB参与SMPP患儿气道炎症改变。气道中NF-κB的水平越高，临床表现越严重，住院时间越长。
