METHODS: This descriptive-analytical cross-sectional was conducted on 15 paraffin blocks of reticular lichen planus lesions, 16 paraffin blocks of erosive OLP lesions, and 8 paraffin blocks of inflammatory fibrous hyperplasia lesions as the control group (39 in total). After immunohistochemical staining for EGFR, samples were simultaneously observed by two maxillofacial pathologist, and the percentage of stained cells, intensity of staining, pattern of staining, and the location of stained cells were obtained.
RESULTS: The Mann-Whitney-U test showed that there was no significant difference in the mean percentage of stained cells between erosive OLP and reticular OLP (P-value = 0.213) and between reticular OLP and control group (P-value = 0.137), but there was a significant difference between erosive OLP and control group (P-value = 0.035). Fisher\'s exact test showed that there was no significant difference between the frequency distribution of staining patterns in three types of lesions (P-value = 0.90). Kruskal-Wallis test showed that there was no significant difference between the intensity of staining in the three groups (P-value = 0.19) and also there was no significant difference between the location of stained cells in different layers of the epithelium in the three groups (P-value = 0.90).
CONCLUSIONS: The results of this study showed that in comparison of reticular OLP, erosive OLP, and the control group there was a significant difference just between erosive OLP and control group in the percentage of stained cells.
方法:对15个网状扁平苔藓病变的石蜡块进行了描述性分析横截面,16个浸润性OLP病变的石蜡块,以炎性纤维增生性病变石蜡块8块为对照组(共39块)。EGFR免疫组化染色后,由两名颌面病理学家同时观察样本,以及染色细胞的百分比,染色强度,染色模式,并获得染色细胞的位置。
结果:Mann-Whitney-U检验表明,糜烂OLP与网状OLP之间(P值=0.213)以及网状OLP与对照组之间(P值=0.137)的平均染色细胞百分比没有显着差异。但糜烂性OLP与对照组之间存在显着差异(P值=0.035)。Fisher精确检验显示,3种病变的染色模式频率分布无显著性差异(P值=0.90)。Kruskal-Wallis检验表明,三组的染色强度之间没有显着差异(P值=0.19),并且染色细胞在上皮不同层中的位置之间也没有显着差异(P值=0.90)。
结论:这项研究的结果表明,与网状OLP相比,侵蚀性OLP,对照组的染色细胞百分比仅在侵蚀性OLP和对照组之间存在显着差异。