Abstract：
OBJECTIVE: Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA). However, in cases of PA, concurrent subclinical Cushing\'s syndrome (SCS) has the potential to confound AVS results. Pentixafor, a CXC chemokine receptor type 4-specific ligand, has been reported as a promising marker to evaluate functional nature of adrenal adenomas. This study aims to investigate the clinical value of Gallium-68 Pentixafor Positron Emission Tomography-Computed Tomography (68Ga-Pentixafor PET/CT) in the localization diagnosis of patients with PA plus SCS.
METHODS: Two patients with a confirmed diagnosis of PA plus SCS underwent AVS and 68Ga-Pentixafor PET/CT.
RESULTS: AVS results revealed no lateralization for both patients while 68Ga-Pentixafor PET/CT showed a unilateral adrenal nodule with increased uptake of 68Ga-Pentixafor. Unilateral adrenalectomy was performed based on the results of 68Ga-Pentixafor PET/CT. Subsequently, complete biochemical remission of autonomous aldosterone and cortisol secretion were achieved in both cases.
CONCLUSIONS: 68Ga-Pentixafor PET/CT shows promising potential for the localization of aldosterone and cortisol co-secreting adrenal adenoma in patients with PA plus SCS.
METHODS: Two patients with a confirmed diagnosis of PA plus SCS underwent AVS and 68Ga-Pentixafor PET/CT.
RESULTS: AVS results revealed no lateralization for both patients while 68Ga-Pentixafor PET/CT showed a unilateral adrenal nodule with increased uptake of 68Ga-Pentixafor. Unilateral adrenalectomy was performed based on the results of 68Ga-Pentixafor PET/CT. Subsequently, complete biochemical remission of autonomous aldosterone and cortisol secretion were achieved in both cases.
CONCLUSIONS: 68Ga-Pentixafor PET/CT shows promising potential for the localization of aldosterone and cortisol co-secreting adrenal adenoma in patients with PA plus SCS.
摘要：
目的：对于原发性醛固酮增多症（PA）的亚型，建议进行肾上腺静脉采样（AVS）。然而,在PA的情况下，并发亚临床库欣综合征（SCS）有可能混淆AVS结果。Pentixafor,CXC趋化因子受体4型特异性配体，已被报道为评估肾上腺腺瘤功能性质的有希望的标志物。本研究旨在探讨正电子发射断层扫描-计算机断层扫描（68Ga-PentixaforPET/CT）在PA加SCS患者定位诊断中的临床价值。
方法：两名确诊为PA加SCS的患者接受了AVS和68Ga-PentixaforPET/CT。
结果：AVS结果显示两名患者均无侧化，而68Ga-PentixaforPET/CT显示单侧肾上腺结节，对68Ga-Pentixafor的摄取增加。根据68Ga-PentixaforPET/CT的结果进行单侧肾上腺切除术。随后，在两种情况下，自主醛固酮和皮质醇分泌均实现了完全的生化缓解。
结论：68Ga-PentixaforPET/CT在PA加SCS患者中显示出潜在的醛固酮和皮质醇共分泌肾上腺腺瘤的定位。
方法：两名确诊为PA加SCS的患者接受了AVS和68Ga-PentixaforPET/CT。
结果：AVS结果显示两名患者均无侧化，而68Ga-PentixaforPET/CT显示单侧肾上腺结节，对68Ga-Pentixafor的摄取增加。根据68Ga-PentixaforPET/CT的结果进行单侧肾上腺切除术。随后，在两种情况下，自主醛固酮和皮质醇分泌均实现了完全的生化缓解。
结论：68Ga-PentixaforPET/CT在PA加SCS患者中显示出潜在的醛固酮和皮质醇共分泌肾上腺腺瘤的定位。
