METHODS: Two patients with a confirmed diagnosis of PA plus SCS underwent AVS and 68Ga-Pentixafor PET/CT.
RESULTS: AVS results revealed no lateralization for both patients while 68Ga-Pentixafor PET/CT showed a unilateral adrenal nodule with increased uptake of 68Ga-Pentixafor. Unilateral adrenalectomy was performed based on the results of 68Ga-Pentixafor PET/CT. Subsequently, complete biochemical remission of autonomous aldosterone and cortisol secretion were achieved in both cases.
CONCLUSIONS: 68Ga-Pentixafor PET/CT shows promising potential for the localization of aldosterone and cortisol co-secreting adrenal adenoma in patients with PA plus SCS.
方法:两名确诊为PA加SCS的患者接受了AVS和68Ga-PentixaforPET/CT。
结果:AVS结果显示两名患者均无侧化,而68Ga-PentixaforPET/CT显示单侧肾上腺结节,对68Ga-Pentixafor的摄取增加。根据68Ga-PentixaforPET/CT的结果进行单侧肾上腺切除术。随后,在两种情况下,自主醛固酮和皮质醇分泌均实现了完全的生化缓解。
结论:68Ga-PentixaforPET/CT在PA加SCS患者中显示出潜在的醛固酮和皮质醇共分泌肾上腺腺瘤的定位。