Abstract：
Autoimmune diseases (AIDs) are immune system disorders where the body exhibits an immune response to its own antigens, causing damage to its own tissues and organs. The pathogenesis of AIDs is incompletely understood. However, recent advances in immune repertoire sequencing (IR-seq) technology have opened-up a new avenue to study the IR. These studies have revealed the prevalence in IR alterations, potentially inducing AIDs by disrupting immune tolerance and thereby contributing to our comprehension of AIDs. IR-seq harbors significant potential for the clinical diagnosis, personalized treatment, and prognosis of AIDs. This article reviews the application and progress of IR-seq in diseases, such as multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes, to enhance our understanding of the pathogenesis of AIDs and offer valuable references for the diagnosis and treatment of AIDs.
摘要：
自身免疫性疾病（AIDs）是免疫系统疾病，身体对自身抗原表现出免疫反应，对自身组织和器官造成损害.AIDs的发病机制尚未完全了解。然而,免疫库测序（IR-seq）技术的最新进展为研究IR开辟了一条新途径。这些研究揭示了IR改变的患病率，可能通过破坏免疫耐受来诱导AIDs，从而有助于我们对AIDs的理解。IR-seq具有临床诊断的巨大潜力，个性化治疗,和艾滋病的预后。本文就IR-seq在疾病中的应用及进展作一综述。比如多发性硬化症,系统性红斑狼疮,类风湿性关节炎,和1型糖尿病，提高对AIDs发病机制的认识,为AIDs的诊断和治疗提供有价值的参考。
