OBJECTIVE: The objectives of this study were to design an AF repair technique to reduce solve the current problems of insufficient mechanical properties and poor sealing capacity.
METHODS: In vitro biomechanical experiments and finite element analysis.
METHODS: The materials used in this study were patches and hydrogels with good biocompatibility and sufficient mechanical properties to withstand loading in the lumbar spine. Five repair techniques were assessed in this study: hydrogel filler (HF), AF patch medial barrier (MB), AF patch medial barrier and hydrogel filler (MB&HF), AF patch medial-lateral barrier (MLB), and AF patch medial-lateral barrier and hydrogel filler (MLB&HF). The repair techniques were subjected to in vitro testing (400 N axial compression and 0-500 N fatigue loading at 5Hz) and finite element analysis (400 N axial compression) to evaluate the effectiveness at repairing large AF defects. The evaluation included repair tightness, spinal stability, and fatigue resistance.
RESULTS: From the in vitro testing, the failure load of the repair techniques was in the following order HF
CONCLUSIONS: The combined use of patches and hydrogels exhibited promising mechanical properties postdiscectomy, providing a promising solution for addressing large AF defects and improving disc stability.
CONCLUSIONS: This study introduces a promising method for repairing large annular fissure (AF) defects after disc herniation, combining patch repair with a hydrogel filler. These techniques hold potential for developing clinical AF repair products to address this challenging issue.
目的:本研究的目的是设计一种AF修复技术,以减少解决当前机械性能不足和密封能力差的问题。
方法:体外生物力学实验和有限元分析。
方法:本研究中使用的材料是贴片和水凝胶,具有良好的生物相容性和足够的机械性能,可以承受腰椎中的载荷。在这项研究中评估了五种修复技术:水凝胶填充剂(HF),AF补片内侧屏障(MB),AF贴片内侧屏障和水凝胶填充剂(MB和HF),AF补片内侧-外侧屏障(MLB),和AF贴片内侧-外侧屏障和水凝胶填充剂(MLB&HF)。对修复技术进行了体外测试(400N轴向压缩和5Hz下的0-500N疲劳载荷)和有限元分析(400N轴向压缩),以评估修复大型AF缺陷的有效性。评估包括修复密封性,脊柱稳定性,和抗疲劳性。
结果:从体外测试来看,修复技术的失效负荷按以下顺序HF
结论:联合使用贴剂和水凝胶在椎间盘切除术后显示出有希望的机械性能,为解决大的AF缺陷和提高光盘稳定性提供了一个有前途的解决方案。
结论:这项研究介绍了一种有前途的方法,用于修复椎间盘突出后的大型环状裂(AF)缺损,将补片修复与水凝胶填充剂相结合。这些技术具有开发临床AF修复产品以解决该挑战性问题的潜力。