Abstract：
The neurogenetics and vision community recently mourned William L. Pak, PhD, whose pioneering work spearheaded the genetic, electrophysiological, and molecular bases of biological processes underpinning vision. This essay provides a historical background to the daunting challenges and personal experiences that carved the path to seminal findings. It also reflects on the intellectual framework, mentoring philosophy, and inspirational legacy of Bill Pak\'s research. An emphasis and perspectives are placed on the discoveries and implications to date of the phosphatidylinositol-specific phospholipase C (PI-PLC), NorpA, and the cyclophilin, NinaA of the fruit fly, Drosophila melanogaster, and their respective mammalian homologues, PI-PLCβ4, and cyclophilin-related protein, Ran-binding protein 2 (Ranbp2) in critical biological processes and diseases of photoreceptors and other neurons.
摘要：
神经遗传学和视觉界最近哀悼威廉·L·帕克，PhD,他的开创性工作引领了遗传学，电生理学,和生物过程的分子基础支撑视觉。本文为艰巨的挑战和个人经验提供了历史背景，这些挑战和经验为开创性发现开辟了道路。它还反映了知识框架，指导哲学，以及比尔·帕克研究的鼓舞人心的遗产。强调和观点放在磷脂酰肌醇特异性磷脂酶C（PIPLC）的发现和意义上，NorpA,和亲环素，果蝇的NinaA，黑腹果蝇,以及它们各自的哺乳动物同源物，PI-PLCβ4和亲环素相关蛋白，Ran结合蛋白2（Ranbp2）在关键的生物过程和光感受器和其他神经元的疾病中。
