Abstract：
The number of therapeutic drugs known to be human teratogens is actually relatively small. This may reflect the rigorous animal testing and well defined labelling. Some of these drugs were identified to have reactive metabolites and this has been postulated, historically, to be their teratogenic mechanism. These drugs include thalidomide, various anticonvulsants and retinoic acid derivatives.Many of these experiments were conducted in a period where chemically reactive metabolites were being intensely investigated and associated with all forms of toxicity. The legacy of this is that these examples are routinely cited as well established mechanisms.Examination of mechanism leads to the conclusion that the teratogenicity in humans of these compounds is likely due to the primary and secondary pharmacology of the parent drug and stable circulating metabolites and that association of reactive metabolites to this toxicity is unwarranted.
摘要：
1.已知为人类致畸剂的治疗药物的数量实际上相对较少。这可能反映了严格的动物测试和明确定义的标签。这些药物中的一些被鉴定为具有反应性代谢物，历史上,是它们的致畸机制.这些药物包括沙利度胺,各种抗惊厥药和维甲酸衍生物2.这些实验中的许多实验是在对化学反应性代谢物进行深入研究并与所有形式的毒性相关的时期进行的。这样做的遗产是，这些例子通常被引用为既定的机制。对机制的研究得出的结论是，这些化合物在人体中的致畸性可能是由于母体药物和稳定的循环代谢物的主要和次要药理学，并且反应性代谢物与这种毒性的联系是没有根据的。
