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Abstract：
OBJECTIVE: To compare the risk of developing subsequent primary lung cancer among cervical cancer patients and the general population.
METHODS: Several databases were searched from inception to April 25, 2023. The standard incidence ratios (SIRs) with 95% confidence intervals (CIs) were combined to identify the risk for second primary lung cancer after cervical carcinoma. Subgroup analyses based on the follow-up period, age, degree of malignancy and source of SIR were conducted. All the statistical analyses were performed with STATA 15.0 software.
RESULTS: A total of 22 retrospective studies involving 864,627 participants were included. The pooled results demonstrated that cervical cancer patients had a significantly greater risk for lung cancer than did the general population (SIR = 2.63, 95% CI: 2.37-2.91, P<0.001). Furthermore, subgroup analyses stratified by follow-up period (<5 years and ≥5 years), age (≤50 years and <50 years), and degree of malignancy (invasive and in situ) also revealed an increased risk of developing lung cancer among cervical carcinoma patients.
CONCLUSIONS: Cervical cancer patients are more likely to develop subsequent primary lung cancer than the general population, regardless of age, follow-up time or degree of malignancy. However, more high-quality prospective studies are still needed to verify our findings.
METHODS: Several databases were searched from inception to April 25, 2023. The standard incidence ratios (SIRs) with 95% confidence intervals (CIs) were combined to identify the risk for second primary lung cancer after cervical carcinoma. Subgroup analyses based on the follow-up period, age, degree of malignancy and source of SIR were conducted. All the statistical analyses were performed with STATA 15.0 software.
RESULTS: A total of 22 retrospective studies involving 864,627 participants were included. The pooled results demonstrated that cervical cancer patients had a significantly greater risk for lung cancer than did the general population (SIR = 2.63, 95% CI: 2.37-2.91, P<0.001). Furthermore, subgroup analyses stratified by follow-up period (<5 years and ≥5 years), age (≤50 years and <50 years), and degree of malignancy (invasive and in situ) also revealed an increased risk of developing lung cancer among cervical carcinoma patients.
CONCLUSIONS: Cervical cancer patients are more likely to develop subsequent primary lung cancer than the general population, regardless of age, follow-up time or degree of malignancy. However, more high-quality prospective studies are still needed to verify our findings.
摘要：
目的：比较宫颈癌患者和普通人群发生后续原发性肺癌的风险。
方法：从开始到2023年4月25日搜索了几个数据库。结合标准发生率（SIR）和95％置信区间（CI），以确定宫颈癌后第二原发性肺癌的风险。基于随访期的亚组分析，年龄,进行了恶性程度和SIR来源。所有统计分析均采用STATA15.0软件进行。
结果：共纳入22项回顾性研究，涉及864,627名参与者。汇总结果表明，宫颈癌患者患肺癌的风险明显高于普通人群（SIR=2.63，95％CI：2.37-2.91，P<0.001）。此外，按随访期（<5年和≥5年）分层的亚组分析，年龄（≤50岁和<50岁），和恶性程度（浸润性和原位）也显示宫颈癌患者患肺癌的风险增加。
结论：宫颈癌患者比普通人群更容易发生后续原发性肺癌，不管年龄,随访时间或恶性程度。然而,我们仍需要更多高质量的前瞻性研究来验证我们的发现.
方法：从开始到2023年4月25日搜索了几个数据库。结合标准发生率（SIR）和95％置信区间（CI），以确定宫颈癌后第二原发性肺癌的风险。基于随访期的亚组分析，年龄,进行了恶性程度和SIR来源。所有统计分析均采用STATA15.0软件进行。
结果：共纳入22项回顾性研究，涉及864,627名参与者。汇总结果表明，宫颈癌患者患肺癌的风险明显高于普通人群（SIR=2.63，95％CI：2.37-2.91，P<0.001）。此外，按随访期（<5年和≥5年）分层的亚组分析，年龄（≤50岁和<50岁），和恶性程度（浸润性和原位）也显示宫颈癌患者患肺癌的风险增加。
结论：宫颈癌患者比普通人群更容易发生后续原发性肺癌，不管年龄,随访时间或恶性程度。然而,我们仍需要更多高质量的前瞻性研究来验证我们的发现.
