PDF(Pubmed)
Abstract：
UNASSIGNED: Obstructive sleep apnea (OSA) is a common condition in older adult (aged >65 years) populations, but more mechanistic research is needed to individualize treatments. Previous evidence has suggested an association between OSA and posttraumatic stress disorder (PTSD) but is limited by possible selection bias. High-quality research on this association with a careful evaluation of possible confounders may yield important mechanistic insight into both conditions and improve treatment efforts.
UNASSIGNED: To investigate the association of current PTSD symptoms and PTSD diagnosis with OSA.
UNASSIGNED: This cross-sectional study of twin pairs discordant for PTSD, which allows for adjustment for familial factors, was conducted using in-laboratory polysomnography from March 20, 2017, to June 3, 2019. The study sample comprised male veteran twins recruited from the Vietnam Era Twin Registry. The data analysis was performed between June 11, 2022, and January 30, 2023.
UNASSIGNED: Symptoms of PTSD in twins who served in the Vietnam War. Diagnosis of PTSD was a secondary exposure.
UNASSIGNED: Obstructive sleep apnea was assessed using the apnea-hypopnea index (AHI) (≥4% oxygen saturation criterion as measured by events per hour) with overnight polysomnography. Symptoms of PTSD were assessed using the PTSD Checklist (PCL) and structured clinical interview for PTSD diagnosis.
UNASSIGNED: A total of 181 male twins (mean [SD] age, 68.4 [2.0] years) including 66 pairs discordant for PTSD symptoms and 15 pairs discordant for a current PTSD diagnosis were evaluated. In models examining the PCL and OSA within pairs and adjusted for body mass index (BMI) and other sociodemographic, cardiovascular, and psychiatric risk factors (including depression), each 15-point increase in PCL was associated with a 4.6 (95% CI, 0.1-9.1) events-per-hour higher AHI. Current PTSD diagnosis was associated with an adjusted 10.5 (95% CI, 5.7-15.3) events-per-hour higher AHI per sleep-hour. Comparable standardized estimates of the association of PTSD symptoms and BMI with AHI per SD increase (1.9 events per hour; 95% CI, 0.5-3.3 events per hour) were found.
UNASSIGNED: This cross-sectional study found an association between PTSD and sleep-disordered breathing. The findings have important public health implications and may also enhance understanding of the many factors that potentially affect OSA pathophysiology.
UNASSIGNED: To investigate the association of current PTSD symptoms and PTSD diagnosis with OSA.
UNASSIGNED: This cross-sectional study of twin pairs discordant for PTSD, which allows for adjustment for familial factors, was conducted using in-laboratory polysomnography from March 20, 2017, to June 3, 2019. The study sample comprised male veteran twins recruited from the Vietnam Era Twin Registry. The data analysis was performed between June 11, 2022, and January 30, 2023.
UNASSIGNED: Symptoms of PTSD in twins who served in the Vietnam War. Diagnosis of PTSD was a secondary exposure.
UNASSIGNED: Obstructive sleep apnea was assessed using the apnea-hypopnea index (AHI) (≥4% oxygen saturation criterion as measured by events per hour) with overnight polysomnography. Symptoms of PTSD were assessed using the PTSD Checklist (PCL) and structured clinical interview for PTSD diagnosis.
UNASSIGNED: A total of 181 male twins (mean [SD] age, 68.4 [2.0] years) including 66 pairs discordant for PTSD symptoms and 15 pairs discordant for a current PTSD diagnosis were evaluated. In models examining the PCL and OSA within pairs and adjusted for body mass index (BMI) and other sociodemographic, cardiovascular, and psychiatric risk factors (including depression), each 15-point increase in PCL was associated with a 4.6 (95% CI, 0.1-9.1) events-per-hour higher AHI. Current PTSD diagnosis was associated with an adjusted 10.5 (95% CI, 5.7-15.3) events-per-hour higher AHI per sleep-hour. Comparable standardized estimates of the association of PTSD symptoms and BMI with AHI per SD increase (1.9 events per hour; 95% CI, 0.5-3.3 events per hour) were found.
UNASSIGNED: This cross-sectional study found an association between PTSD and sleep-disordered breathing. The findings have important public health implications and may also enhance understanding of the many factors that potentially affect OSA pathophysiology.
摘要：
■阻塞性睡眠呼吸暂停（OSA）是老年人（年龄>65岁）人群的常见病，但是需要更多的机械研究来个性化治疗。先前的证据表明OSA与创伤后应激障碍（PTSD）之间存在关联，但受到可能的选择偏见的限制。对这种关联的高质量研究以及对可能的混杂因素的仔细评估可能会对两种情况产生重要的机械洞察力，并改善治疗努力。
■探讨当前PTSD症状和PTSD诊断与OSA的关系。
■这项针对PTSD的双胞胎对不一致的横断面研究，这允许调整家庭因素，于2017年3月20日至2019年6月3日使用实验室多导睡眠图进行。研究样本包括从越南时代双胞胎登记处招募的男性资深双胞胎。数据分析在2022年6月11日至2023年1月30日之间进行。
■在越南战争中服役的双胞胎的PTSD症状。PTSD的诊断是二次暴露。
■使用通宵多导睡眠图的呼吸暂停低通气指数（AHI）（以每小时事件测量≥4％的氧饱和度标准）评估阻塞性睡眠呼吸暂停。使用PTSD检查表（PCL）和用于PTSD诊断的结构化临床访谈评估PTSD的症状。
■总共181对男性双胞胎（平均[SD]年龄，68.4[2.0]年），包括66对PTSD症状不一致和15对当前PTSD诊断不一致。在对PCL和OSA进行配对检查并根据体重指数（BMI）和其他社会人口统计学进行调整的模型中，心血管,和精神危险因素（包括抑郁症），PCL每增加15分,AHI每小时增加4.6(95%CI,0.1~9.1)个事件相关.当前的PTSD诊断与每睡眠小时的AHI每小时增加10.5（95％CI，5.7-15.3）事件相关。发现PTSD症状和BMI与每SD增加一次AHI的相关性的标准化估计（每小时1.9个事件；95％CI，每小时0.5-3.3个事件）。
■这项横断面研究发现PTSD与睡眠呼吸紊乱之间存在关联。这些发现具有重要的公共卫生意义，也可能增强对潜在影响OSA病理生理学的许多因素的理解。
■探讨当前PTSD症状和PTSD诊断与OSA的关系。
■这项针对PTSD的双胞胎对不一致的横断面研究，这允许调整家庭因素，于2017年3月20日至2019年6月3日使用实验室多导睡眠图进行。研究样本包括从越南时代双胞胎登记处招募的男性资深双胞胎。数据分析在2022年6月11日至2023年1月30日之间进行。
■在越南战争中服役的双胞胎的PTSD症状。PTSD的诊断是二次暴露。
■使用通宵多导睡眠图的呼吸暂停低通气指数（AHI）（以每小时事件测量≥4％的氧饱和度标准）评估阻塞性睡眠呼吸暂停。使用PTSD检查表（PCL）和用于PTSD诊断的结构化临床访谈评估PTSD的症状。
■总共181对男性双胞胎（平均[SD]年龄，68.4[2.0]年），包括66对PTSD症状不一致和15对当前PTSD诊断不一致。在对PCL和OSA进行配对检查并根据体重指数（BMI）和其他社会人口统计学进行调整的模型中，心血管,和精神危险因素（包括抑郁症），PCL每增加15分,AHI每小时增加4.6(95%CI,0.1~9.1)个事件相关.当前的PTSD诊断与每睡眠小时的AHI每小时增加10.5（95％CI，5.7-15.3）事件相关。发现PTSD症状和BMI与每SD增加一次AHI的相关性的标准化估计（每小时1.9个事件；95％CI，每小时0.5-3.3个事件）。
■这项横断面研究发现PTSD与睡眠呼吸紊乱之间存在关联。这些发现具有重要的公共卫生意义，也可能增强对潜在影响OSA病理生理学的许多因素的理解。
