Abstract：
Chronic cough is a common disorder lasting more than 8 weeks and affecting all age groups. The evidence supporting the role of neutrophils in chronic cough pathology is based on many patients with chronic cough developing airway neutrophilia. How neutrophils influence the development of chronic cough is unknown. However, they are likely involved in multiple aspects of cough etiology, including promoting airway inflammation, airway remodeling, hyper-responsiveness, local neurogenic inflammation, and other possible mechanisms. Neutrophilic airway inflammation is also associated with refractory cough, poor control of underlying diseases (e.g., asthma), and insensitivity to cough suppressant therapy. The potential for targeting neutrophils in chronic cough needs exploration, including developing new drugs targeting one or more neutrophil-mediated pathways or altering the neutrophil phenotype to alleviate chronic cough. How the airway microbiome differs, plays a role, and interacts with neutrophils in different cough etiologies is poorly understood. Future studies should focus on understanding the relationship between the airway microbiome and neutrophils.
摘要：
慢性咳嗽是一种常见疾病，持续时间超过8周，影响所有年龄组。支持中性粒细胞在慢性咳嗽病理中的作用的证据是基于许多慢性咳嗽发展为气道中性粒细胞增多症的患者。中性粒细胞如何影响慢性咳嗽的发展尚不清楚。然而,它们可能涉及咳嗽病因的多个方面，包括促进气道炎症，气道重塑,超响应性,局部神经源性炎症，和其他可能的机制。嗜中性粒细胞气道炎症也与难治性咳嗽有关，对基础疾病控制不力(例如，哮喘)，对止咳药治疗不敏感。在慢性咳嗽中靶向中性粒细胞的潜力需要探索，包括开发针对一种或多种中性粒细胞介导途径或改变中性粒细胞表型以缓解慢性咳嗽的新药。气道微生物组的不同，扮演一个角色,以及与中性粒细胞在不同咳嗽病因中的相互作用知之甚少。未来的研究应集中在了解气道微生物组和中性粒细胞之间的关系。
