Abstract：
Ionizing radiation produces deleterious effects on living organisms. The present investigation has been carried out to study the prophylactic as well as the therapeutic effects of treated rats with quercetin (Quer) and curcumin (Cur), which are two medicinal herbs known for their antioxidant activities against damages induced by whole-body fractionated gamma irradiation. Exposure of rats to whole-body gamma irradiation induced a significant decrease in erythrocyte (RBC), leukocyte (WBCs), platelet count (Plt), hemoglobin concentration (Hb), hematocrit (Hct %), mean erythrocyte hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and mean erythrocyte volume (MCV); a high increase in plasma thiobarbituric acid reactive substances (TBARS); a nonsignificant statistical decrease in the mean value of serum glutathione (GSH); a significant increase in plasma alanine transferase (ALT), aspartate transferase (AST), alkaline phosphates (ALP), serum total protein, serum total cholesterol levels, total triglycerides levels, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels; and with marked histological changes and structural changes measured by Fourier transform infrared (FTIR). Applying both quercetin and curcumin pre- and postexposure to gamma radiation revealed a remarkable improvement in all the studied parameters. The cellular damage by gamma radiation is greatly mitigated by the coadministration of curcumin and quercetin before radiation exposure.
摘要：
电离辐射对生物体产生有害影响。本研究已进行，以研究槲皮素（Quer）和姜黄素（Cur）治疗大鼠的预防和治疗效果，这是两种以抗氧化活性而闻名的草药，可抵抗全身分馏伽马射线辐射引起的损害。大鼠暴露于全身γ射线照射诱导红细胞（RBC）显着减少，白细胞（WBC），血小板计数(Plt),血红蛋白浓度（Hb），血细胞比容(Hct%),平均红细胞血红蛋白（MCH），平均红细胞血红蛋白浓度（MCHC），和平均红细胞体积（MCV）；血浆硫代巴比妥酸反应性物质（TBARS）的高度增加；血清谷胱甘肽（GSH）的平均值无统计学意义的降低；血浆丙氨酸转移酶（ALT）的显着增加，天冬氨酸转移酶（AST），碱性磷酸盐（ALP），血清总蛋白，血清总胆固醇水平，总甘油三酯水平，高密度脂蛋白（HDL），和低密度脂蛋白（LDL）水平；并且通过傅立叶变换红外（FTIR）测量具有明显的组织学变化和结构变化。在暴露于γ辐射之前和之后应用槲皮素和姜黄素显示所有研究参数均有显着改善。通过在辐射暴露之前共同施用姜黄素和槲皮素,极大地减轻了γ辐射对细胞的损伤。
