Abstract：
Esophageal squamous cell carcinoma (ESCC) is a common malignancy of the gastrointestinal tract with a single therapeutic option and a lack of effective clinical therapeutic biomarkers. Extracellular matrix (ECM) remodeling plays a pro-carcinogenic role in a variety of malignancies, but its role in esophageal squamous carcinoma remains to be elucidated. In this study, we examined the expression levels of ECM remodeling markers in 71 pairs of esophageal squamous carcinoma tissues and normal tissues adjacent to the carcinoma using immunohistochemical staining, and analyzed their relationship with clinicopathological features and prognosis. The results suggested that extracellular matrix remodeling markers (integrin αV, fibronectin, MMP9) were abnormally highly expressed in esophageal squamous carcinoma tissues. There was a statistically significant difference between the positive expression of ECM remodeling and the TNM stage of esophageal squamous carcinoma, and there was no statistically significant correlation with age, gender and carcinoembryonic antigen expression, differentiation degree, T stage, and lymph node metastasis. Overall survival rate and overall survival time were significantly lower in patients with positive ECM remodeling expression, which was an independent risk factor for poor prognosisof esophageal squamous carcinoma.
摘要：
食管鳞状细胞癌（ESCC）是一种常见的胃肠道恶性肿瘤，其治疗选择单一，缺乏有效的临床治疗生物标志物。细胞外基质（ECM）重塑在多种恶性肿瘤中起着促致癌作用，但其在食管鳞癌中的作用仍有待阐明。在这项研究中,我们使用免疫组织化学染色检测了71对食管鳞癌组织和癌旁正常组织中ECM重塑标志物的表达水平，并分析其与临床病理特征及预后的关系。结果表明，细胞外基质重塑标志物(整合素αV，纤连蛋白,MMP9)在食管鳞癌组织中异常高表达。ECM重塑阳性表达与食管鳞癌TNM分期有统计学差别，与年龄没有统计学上的显著相关性，性别和癌胚抗原表达，分化程度，T级,淋巴结转移。ECM重塑阳性表达患者的总生存率和总生存时间显著降低,是食管鳞癌预后不良的独立危险因素。
