Abstract：
This case report describes rare concomitant allergic fungal rhinosinusitis (AFRS) and chronic granulomatous invasive fungal sinusitis (CGIFS) in a 34-year-old woman with acute lymphoblastic leukemia and graft-versus-host disease (GVHD) post bone marrow transplantation. Initially presenting with rhinorrhea and nasal obstruction, the patient was diagnosed with AFRS in the right maxillary sinus, followed by a postoperative course of CGIFS in the left nasal cavity, showcasing the unique occurrence. She was not immunocompromised during diagnosis. CGIFS may have occurred because of surgery; however, voriconazole led to significant improvement. This case highlights noninvasive and invasive fungal infections in patients with chronic rhinosinusitis and a history of GVHD and underscores the complexity of diagnosing and managing such cases.
摘要：
该病例报告描述了一名34岁女性急性淋巴细胞白血病和移植物抗宿主病（GVHD）骨髓移植后罕见的并发过敏性真菌性鼻鼻窦炎（AFRS）和慢性肉芽肿性侵袭性真菌性鼻窦炎（CGIFS）。最初表现为鼻漏和鼻塞，患者被诊断为右上颌窦AFRS，随后在左鼻腔进行了CGIFS的术后疗程，展示独特的事件。她在诊断期间没有免疫受损。CGIFS可能是由于手术而发生的；然而，伏立康唑导致显著改善。该病例突出了慢性鼻窦炎和GVHD病史患者的非侵袭性和侵袭性真菌感染，并强调了诊断和治疗此类病例的复杂性。
