PDF(Pubmed)
Abstract：
A 71-year-old male had disseminated multiple organ dysfunction syndrome (MODS). Following treatment with cefotaxime and piperacillin-tazobactam, his symptoms have worsened instead. Multiple organ failure caused by Japanese Spotted Fever (JSF) was diagnosed based on metagenomic next-generation sequencing (mNGS), we rapidly treated the patient with doxycycline. Thereafter, his symptoms gradually improved. In this report, we emphasized the importance of rapid microbial diagnostic tools and the early use of tetracyclines for the treatment of JSF.
摘要：
一名71岁的男性患有播散性多器官功能障碍综合征（MODS）。头孢噻肟和哌拉西林他唑巴坦治疗后，他的症状反而恶化了。基于宏基因组下一代测序（mNGS）诊断由日本斑点热（JSF）引起的多器官衰竭，我们迅速用多西环素治疗病人。此后,他的症状逐渐好转。在这份报告中,我们强调了快速微生物诊断工具和早期使用四环素治疗JSF的重要性.
