PDF(Pubmed)
Abstract：
UNASSIGNED: Manitoba saw the highest number of new HIV diagnoses in the province\'s history in 2021 and is the only Canadian province not meeting any of the previous UNAIDS 90-90-90 targets. Our goal was to describe sex differences and syndemic conditions within an incident HIV cohort in Manitoba, and the HIV treatment initiation and undetectable viral load outcomes.
UNASSIGNED: This was a retrospective cohort study of all people 18 years and older newly diagnosed with HIV in Manitoba, Canada between January 1st, 2018 and December 31st, 2021. Data was collected as follows: before HIV diagnosis: chlamydia, gonorrhoea, syphilis, and/or hepatitis C antibodies. At the time of HIV diagnosis: age, sex, gender, race/ethnicity, sexual orientation. During follow-up: CD4 counts, viral load, HIV treatment, hospitalizations, and number of visits to HIV care. Main exposures evaluated: methamphetamine use, injection drug use, houselessness, and mental health conditions. Outcomes: started antiretroviral treatment and achieved an undetectable viral load. A descriptive statistical analysis was used.
UNASSIGNED: There were 404 new HIV diagnoses in Manitoba from 2018 to 2021; 44.8% were female, 55.2% male; 76.% self-identified as Indigenous, 13.4% white/European, 4.7% African/black; 86.6% cis-gender; 60.9% heterosexual, 13.4% gay, bisexual and men who have sex with men, and 1.7% lesbian. Injection drug use was reported by 71.8% and 43.5% of females and males respectively. Methamphetamine was the most frequently injected drug (62.4%). Amongst females, 81.8% experienced at least one of the following: houselessness (43.1%), mental health comorbidities (46.4%), and injection drug use (71.8%). Only 64.9% of all individuals had an undetectable viral load (61.1% females and 67.9% males), 56.5% among people experiencing houselessness, 59% among young people (≤29 years), and 60.1% among people who inject drugs.
UNASSIGNED: People newly diagnosed with HIV in Manitoba are disproportionately experiencing houselessness, mental illness, and injection drug use (mostly methamphetamine). This pattern is more pronounced for female individuals. These findings highlight the need for syndemic and gender-specific approaches, simultaneously addressing social and health conditions, to treat HIV.
UNASSIGNED: This work was supported by the Canadian Institutes of Health Research, The Manitoba Medical Service Foundation, The James Farley Memorial Fund and the Canada Research Chairs Program.
UNASSIGNED: This was a retrospective cohort study of all people 18 years and older newly diagnosed with HIV in Manitoba, Canada between January 1st, 2018 and December 31st, 2021. Data was collected as follows: before HIV diagnosis: chlamydia, gonorrhoea, syphilis, and/or hepatitis C antibodies. At the time of HIV diagnosis: age, sex, gender, race/ethnicity, sexual orientation. During follow-up: CD4 counts, viral load, HIV treatment, hospitalizations, and number of visits to HIV care. Main exposures evaluated: methamphetamine use, injection drug use, houselessness, and mental health conditions. Outcomes: started antiretroviral treatment and achieved an undetectable viral load. A descriptive statistical analysis was used.
UNASSIGNED: There were 404 new HIV diagnoses in Manitoba from 2018 to 2021; 44.8% were female, 55.2% male; 76.% self-identified as Indigenous, 13.4% white/European, 4.7% African/black; 86.6% cis-gender; 60.9% heterosexual, 13.4% gay, bisexual and men who have sex with men, and 1.7% lesbian. Injection drug use was reported by 71.8% and 43.5% of females and males respectively. Methamphetamine was the most frequently injected drug (62.4%). Amongst females, 81.8% experienced at least one of the following: houselessness (43.1%), mental health comorbidities (46.4%), and injection drug use (71.8%). Only 64.9% of all individuals had an undetectable viral load (61.1% females and 67.9% males), 56.5% among people experiencing houselessness, 59% among young people (≤29 years), and 60.1% among people who inject drugs.
UNASSIGNED: People newly diagnosed with HIV in Manitoba are disproportionately experiencing houselessness, mental illness, and injection drug use (mostly methamphetamine). This pattern is more pronounced for female individuals. These findings highlight the need for syndemic and gender-specific approaches, simultaneously addressing social and health conditions, to treat HIV.
UNASSIGNED: This work was supported by the Canadian Institutes of Health Research, The Manitoba Medical Service Foundation, The James Farley Memorial Fund and the Canada Research Chairs Program.
摘要：
曼尼托巴省在2021年的历史上发现了最多的新艾滋病毒诊断，并且是加拿大唯一一个没有达到联合国艾滋病规划署90-90-90目标的省份。我们的目标是描述曼尼托巴省HIV事件队列中的性别差异和综合症条件，以及HIV治疗的开始和无法检测到的病毒载量结果。
■这是一项回顾性队列研究，对曼尼托巴省所有18岁及以上新诊断为HIV的人进行了研究，加拿大1月1日之间,2018年12月31日,2021年。数据收集如下：HIV诊断前：衣原体，淋病,梅毒,和/或丙型肝炎抗体。在HIV诊断时：年龄，性别,性别,种族/民族,性取向。在随访期间：CD4计数，病毒载量,艾滋病毒治疗，住院治疗,以及访问艾滋病毒护理的次数。评估的主要暴露：甲基苯丙胺的使用，注射药物使用，无家可归，和心理健康状况。结果：开始抗逆转录病毒治疗并达到检测不到的病毒载量。使用描述性统计分析。
■从2018年到2021年，曼尼托巴省有404例新的艾滋病毒诊断；44.8%是女性，55.2%男性；76。%自我认定为土著，13.4%白色/欧洲，4.7%非洲/黑人；86.6%顺式；60.9%异性恋，13.4%同性恋,双性恋者和与男人发生性关系的男人，和1.7%的女同性恋。据报道，女性和男性的注射药物使用率分别为71.8%和43.5%。甲基苯丙胺是最常注射的药物（62.4％）。在女性中，81.8%的人经历了以下至少一种情况:无家可归(43.1%)，精神健康合并症(46.4%)，和注射药物使用(71.8%)。只有64.9%的人有检测不到的病毒载量（61.1%的女性和67.9%的男性），56.5%的人经历无家可归，59％的年轻人（≤29岁），注射毒品的人占60.1%。
■曼尼托巴省新诊断出艾滋病毒的人正经历着不成比例的无家可归，精神疾病,和注射毒品使用（主要是甲基苯丙胺）。这种模式对于女性个体更为明显。这些发现强调了对联合和针对性别的方法的需求，同时解决社会和卫生条件，治疗艾滋病毒。
■这项工作得到了加拿大卫生研究院的支持，曼尼托巴医疗服务基金会，詹姆斯·法利纪念基金和加拿大研究主席计划。
■这是一项回顾性队列研究，对曼尼托巴省所有18岁及以上新诊断为HIV的人进行了研究，加拿大1月1日之间,2018年12月31日,2021年。数据收集如下：HIV诊断前：衣原体，淋病,梅毒,和/或丙型肝炎抗体。在HIV诊断时：年龄，性别,性别,种族/民族,性取向。在随访期间：CD4计数，病毒载量,艾滋病毒治疗，住院治疗,以及访问艾滋病毒护理的次数。评估的主要暴露：甲基苯丙胺的使用，注射药物使用，无家可归，和心理健康状况。结果：开始抗逆转录病毒治疗并达到检测不到的病毒载量。使用描述性统计分析。
■从2018年到2021年，曼尼托巴省有404例新的艾滋病毒诊断；44.8%是女性，55.2%男性；76。%自我认定为土著，13.4%白色/欧洲，4.7%非洲/黑人；86.6%顺式；60.9%异性恋，13.4%同性恋,双性恋者和与男人发生性关系的男人，和1.7%的女同性恋。据报道，女性和男性的注射药物使用率分别为71.8%和43.5%。甲基苯丙胺是最常注射的药物（62.4％）。在女性中，81.8%的人经历了以下至少一种情况:无家可归(43.1%)，精神健康合并症(46.4%)，和注射药物使用(71.8%)。只有64.9%的人有检测不到的病毒载量（61.1%的女性和67.9%的男性），56.5%的人经历无家可归，59％的年轻人（≤29岁），注射毒品的人占60.1%。
■曼尼托巴省新诊断出艾滋病毒的人正经历着不成比例的无家可归，精神疾病,和注射毒品使用（主要是甲基苯丙胺）。这种模式对于女性个体更为明显。这些发现强调了对联合和针对性别的方法的需求，同时解决社会和卫生条件，治疗艾滋病毒。
■这项工作得到了加拿大卫生研究院的支持，曼尼托巴医疗服务基金会，詹姆斯·法利纪念基金和加拿大研究主席计划。
