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Abstract：
UNASSIGNED: The burden of ischemic stroke (IS) linked to high consumption of red meat is on the rise. This study aimed to analyze the mortality and disability-adjusted life years (DALYs) trends for IS attributed to high red meat intake in China between 1990 and 2019 and to compare these trends with global trends.
UNASSIGNED: This study extracted data on IS attributed to diets high in red meat in China from 1990 to 2019 from the Global Burden of Disease Study (GBD) database. Key measures, including mortality, DALYs, age-standardized mortality rates (ASMR), and age-standardized DALYs rates (ASDR), were used to estimate the disease burden. The estimated annual percentage change and joinpoint regression models were employed to assess the trends over time. An age-period-cohort analysis was used to assess the contribution of a diet high in red meat to the age, period, and cohort effects of IS ASMR and ASDR.
UNASSIGNED: Between 1990 and 2019, deaths and DALYs from IS attributed to a diet high in red meat in China, along with corresponding age-standardized rates, significantly increased. The overall estimated annual percentage change for the total population and across sex categories ranged from 1.01 to 2.08. The average annual percentage changes for overall ASDR and ASMR were 1.4 and 1.33, respectively, with male ASDR and ASMR average annual percentage changes at 1.69 and 1.69, respectively. Contrastingly, female ASDR and ASMR average annual percentage changes were 1.07 and 0.87, respectively. Except for a few periods of significant decrease in females, all other periods indicated a significant increase or nonsignificant changes. Incidence of IS linked to a diet high in red meat rose sharply with age, displaying increasing period and cohort effects in ASDR. Female ASMR period and cohort effect ratios initially increased and then decreased, whereas the male ratio showed an upward trend.
UNASSIGNED: This study comprehensively analyzed epidemiological characteristics that indicated a marked increase in mortality and DALYs from IS attributable to high red meat consumption, contrasting with a global downtrend. This increase was more pronounced in males than females. This research provides valuable insights for enhancing IS prevention in China.
UNASSIGNED: This study extracted data on IS attributed to diets high in red meat in China from 1990 to 2019 from the Global Burden of Disease Study (GBD) database. Key measures, including mortality, DALYs, age-standardized mortality rates (ASMR), and age-standardized DALYs rates (ASDR), were used to estimate the disease burden. The estimated annual percentage change and joinpoint regression models were employed to assess the trends over time. An age-period-cohort analysis was used to assess the contribution of a diet high in red meat to the age, period, and cohort effects of IS ASMR and ASDR.
UNASSIGNED: Between 1990 and 2019, deaths and DALYs from IS attributed to a diet high in red meat in China, along with corresponding age-standardized rates, significantly increased. The overall estimated annual percentage change for the total population and across sex categories ranged from 1.01 to 2.08. The average annual percentage changes for overall ASDR and ASMR were 1.4 and 1.33, respectively, with male ASDR and ASMR average annual percentage changes at 1.69 and 1.69, respectively. Contrastingly, female ASDR and ASMR average annual percentage changes were 1.07 and 0.87, respectively. Except for a few periods of significant decrease in females, all other periods indicated a significant increase or nonsignificant changes. Incidence of IS linked to a diet high in red meat rose sharply with age, displaying increasing period and cohort effects in ASDR. Female ASMR period and cohort effect ratios initially increased and then decreased, whereas the male ratio showed an upward trend.
UNASSIGNED: This study comprehensively analyzed epidemiological characteristics that indicated a marked increase in mortality and DALYs from IS attributable to high red meat consumption, contrasting with a global downtrend. This increase was more pronounced in males than females. This research provides valuable insights for enhancing IS prevention in China.
摘要：
■与大量食用红肉有关的缺血性中风（IS）负担正在上升。这项研究旨在分析1990年至2019年间中国红肉摄入量较高的IS的死亡率和残疾调整寿命年（DALYs）趋势，并将这些趋势与全球趋势进行比较。
■这项研究从全球疾病负担研究（GBD）数据库中提取了1990年至2019年中国高红肉饮食的IS数据。关键措施,包括死亡率,DALYs,年龄标准化死亡率(ASMR)，和年龄标准化的DALYs比率(ASDR)，用于估计疾病负担。采用估计的年度百分比变化和连接点回归模型来评估随时间的趋势。使用年龄-时期-队列分析来评估高红肉饮食对年龄的贡献，period,ISASMR和ASDR的队列效应。
■在1990年至2019年之间，IS的死亡和DALY归因于中国红肉含量高的饮食，以及相应的年龄标准化率，显著增加。总人口和不同性别类别的总体估计年度百分比变化范围为1.01至2.08。总体ASDR和ASMR的平均年度变化百分比分别为1.4和1.33，男性ASDR和ASMR的年平均百分比变化分别为1.69和1.69。相反，女性ASDR和ASMR年平均百分比变化分别为1.07和0.87.除了几个时期的女性显着减少，所有其他时期均显示显著增加或非显著变化。随着年龄的增长，与高红肉饮食相关的IS发病率急剧上升，在ASDR中显示增加的周期和队列效应。女性ASMR期和队列效应比最初增加，然后下降，而男性比例呈上升趋势。
■这项研究全面分析了流行病学特征，这些特征表明，由于红肉消费量高，IS的死亡率和DALYs显着增加，与全球下降趋势形成鲜明对比。男性的这种增加比女性更明显。这项研究为加强中国的IS预防提供了有价值的见解。
■这项研究从全球疾病负担研究（GBD）数据库中提取了1990年至2019年中国高红肉饮食的IS数据。关键措施,包括死亡率,DALYs,年龄标准化死亡率(ASMR)，和年龄标准化的DALYs比率(ASDR)，用于估计疾病负担。采用估计的年度百分比变化和连接点回归模型来评估随时间的趋势。使用年龄-时期-队列分析来评估高红肉饮食对年龄的贡献，period,ISASMR和ASDR的队列效应。
■在1990年至2019年之间，IS的死亡和DALY归因于中国红肉含量高的饮食，以及相应的年龄标准化率，显著增加。总人口和不同性别类别的总体估计年度百分比变化范围为1.01至2.08。总体ASDR和ASMR的平均年度变化百分比分别为1.4和1.33，男性ASDR和ASMR的年平均百分比变化分别为1.69和1.69。相反，女性ASDR和ASMR年平均百分比变化分别为1.07和0.87.除了几个时期的女性显着减少，所有其他时期均显示显著增加或非显著变化。随着年龄的增长，与高红肉饮食相关的IS发病率急剧上升，在ASDR中显示增加的周期和队列效应。女性ASMR期和队列效应比最初增加，然后下降，而男性比例呈上升趋势。
■这项研究全面分析了流行病学特征，这些特征表明，由于红肉消费量高，IS的死亡率和DALYs显着增加，与全球下降趋势形成鲜明对比。男性的这种增加比女性更明显。这项研究为加强中国的IS预防提供了有价值的见解。
