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Abstract：
UNASSIGNED: In this study we aimed to evaluate the postoperative safety of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of peritoneal surface malignancies (PSM), and analyzed the risk factors and pathogen resistance associated with bloodstream infections.
UNASSIGNED: We retrospectively analyzed the incidence of postoperative bloodstream infections in 1500 patients undergoing CRS and HIPEC for PSM. We utilized univariate and multivariate analyses to screen for independent risk factors associated with postoperative bloodstream infections in CRS combined with HIPEC.
UNASSIGNED: Among the 1500 cases of individuals undergoing CRS combined with HIPEC, 207 cases (13.8%) experienced bloodstream infections. A total of 233 strains of pathogens were isolated and cultured, consisting of 151 gram-positive cocci, 52 gram-negative bacilli, and 30 fungi. Coagulase-negative staphylococci (SCN) were the gram-positive cocci (54.94%), while Klebsiella pneumoniae subsp. Pneumoniae (7.30%) and Escherichia coli (5.58%) dominated the Gram-negative bacilli. Candida albicans was the predominant fungus. Staphylococci exhibited high sensitivity to tigecycline, linezolid, vancomycin, and quinupristin/dalfopristin. However, K. pneumoniae and E. coli were resistant to imipenem. Furthermore, five parameters were associated with the development of bloodstream infections: age (P = 0.040), surgical history (P = 0.033), prior tumor treatment (P < 0.001), tumor tissue type (P = 0.034), and completeness of cytoreduction (CC) score (P = 0.004). Among these, age (P = 0.013), prior tumor treatment (P = 0.001), tumor tissue type (P = 0.032), and CC score (P = 0.002) emerged as independent risk factors for postoperative bloodstream infections in patients undergoing CRS combined with HIPEC.
UNASSIGNED: Postoperative bloodstream infections in patients with PSM undergoing CRS combined with HIPEC are predominantly attributed to SCN, K. pneumoniae subsp. Pneumoniae, and C. albicans. Notably, Enterobacteriaceae exhibited resistance to carbapenem. Independent risk factors for postoperative infections in PSM include age, prior tumor treatment, tumor tissue type, and completeness of cytoreduction score.
UNASSIGNED: We retrospectively analyzed the incidence of postoperative bloodstream infections in 1500 patients undergoing CRS and HIPEC for PSM. We utilized univariate and multivariate analyses to screen for independent risk factors associated with postoperative bloodstream infections in CRS combined with HIPEC.
UNASSIGNED: Among the 1500 cases of individuals undergoing CRS combined with HIPEC, 207 cases (13.8%) experienced bloodstream infections. A total of 233 strains of pathogens were isolated and cultured, consisting of 151 gram-positive cocci, 52 gram-negative bacilli, and 30 fungi. Coagulase-negative staphylococci (SCN) were the gram-positive cocci (54.94%), while Klebsiella pneumoniae subsp. Pneumoniae (7.30%) and Escherichia coli (5.58%) dominated the Gram-negative bacilli. Candida albicans was the predominant fungus. Staphylococci exhibited high sensitivity to tigecycline, linezolid, vancomycin, and quinupristin/dalfopristin. However, K. pneumoniae and E. coli were resistant to imipenem. Furthermore, five parameters were associated with the development of bloodstream infections: age (P = 0.040), surgical history (P = 0.033), prior tumor treatment (P < 0.001), tumor tissue type (P = 0.034), and completeness of cytoreduction (CC) score (P = 0.004). Among these, age (P = 0.013), prior tumor treatment (P = 0.001), tumor tissue type (P = 0.032), and CC score (P = 0.002) emerged as independent risk factors for postoperative bloodstream infections in patients undergoing CRS combined with HIPEC.
UNASSIGNED: Postoperative bloodstream infections in patients with PSM undergoing CRS combined with HIPEC are predominantly attributed to SCN, K. pneumoniae subsp. Pneumoniae, and C. albicans. Notably, Enterobacteriaceae exhibited resistance to carbapenem. Independent risk factors for postoperative infections in PSM include age, prior tumor treatment, tumor tissue type, and completeness of cytoreduction score.
摘要：
■在这项研究中，我们旨在评估细胞减灭术（CRS）联合腹腔热化疗（HIPEC）治疗腹膜表面恶性肿瘤（PSM）的术后安全性，并对血流感染的危险因素及病原菌耐药性进行分析。
■我们回顾性分析了1500例接受CRS和HIPEC治疗的PSM患者术后血流感染的发生率。我们利用单变量和多变量分析来筛选与CRS合并HIPEC术后血流感染相关的独立危险因素。
■在接受CRS合并HIPEC的1500例患者中，207例（13.8%）发生血流感染。共分离培养病原菌233株,由151个革兰氏阳性球菌组成，52革兰阴性杆菌,和30种真菌。革兰阳性球菌(54.94%)为凝固酶阴性葡萄球菌(SCN),而肺炎克雷伯菌亚种。肺炎(7.30%)和大肠埃希菌(5.58%)以革兰阴性杆菌为主。白色念珠菌是主要真菌。葡萄球菌对替加环素表现出高度敏感性，利奈唑胺,万古霉素,和奎尼普汀/达福普汀。然而,肺炎克雷伯菌和大肠杆菌对亚胺培南耐药。此外，五个参数与血流感染的发展相关：年龄（P=0.040），手术史（P=0.033），先前的肿瘤治疗（P<0.001），肿瘤组织类型(P=0.034),和细胞减灭术（CC）评分的完整性（P=0.004）。其中,年龄（P=0.013），先前的肿瘤治疗（P=0.001），肿瘤组织类型（P=0.032），和CC评分(P=0.002)是CRS合并HIPEC患者术后血流感染的独立危险因素。
■接受CRS合并HIPEC的PSM患者的术后血流感染主要归因于SCN，肺炎克雷伯菌亚种。肺炎,还有白色念珠菌.值得注意的是,肠杆菌科细菌对碳青霉烯具有抗性。PSM术后感染的独立危险因素包括年龄、先前的肿瘤治疗，肿瘤组织类型，和细胞减少评分的完整性。
■我们回顾性分析了1500例接受CRS和HIPEC治疗的PSM患者术后血流感染的发生率。我们利用单变量和多变量分析来筛选与CRS合并HIPEC术后血流感染相关的独立危险因素。
■在接受CRS合并HIPEC的1500例患者中，207例（13.8%）发生血流感染。共分离培养病原菌233株,由151个革兰氏阳性球菌组成，52革兰阴性杆菌,和30种真菌。革兰阳性球菌(54.94%)为凝固酶阴性葡萄球菌(SCN),而肺炎克雷伯菌亚种。肺炎(7.30%)和大肠埃希菌(5.58%)以革兰阴性杆菌为主。白色念珠菌是主要真菌。葡萄球菌对替加环素表现出高度敏感性，利奈唑胺,万古霉素,和奎尼普汀/达福普汀。然而,肺炎克雷伯菌和大肠杆菌对亚胺培南耐药。此外，五个参数与血流感染的发展相关：年龄（P=0.040），手术史（P=0.033），先前的肿瘤治疗（P<0.001），肿瘤组织类型(P=0.034),和细胞减灭术（CC）评分的完整性（P=0.004）。其中,年龄（P=0.013），先前的肿瘤治疗（P=0.001），肿瘤组织类型（P=0.032），和CC评分(P=0.002)是CRS合并HIPEC患者术后血流感染的独立危险因素。
■接受CRS合并HIPEC的PSM患者的术后血流感染主要归因于SCN，肺炎克雷伯菌亚种。肺炎,还有白色念珠菌.值得注意的是,肠杆菌科细菌对碳青霉烯具有抗性。PSM术后感染的独立危险因素包括年龄、先前的肿瘤治疗，肿瘤组织类型，和细胞减少评分的完整性。
