PDF(Pubmed)
Abstract：
Tinea capitis, primarily caused by dermatophytes such as Trichophyton and Microsporum species, is a superficial fungal infection affecting the scalp and hair, commonly observed in prepubertal children but rare in adults. Here we report a unique case of an adult female with tinea capitis presenting as diffused alopecia and erythema inflammation on the scalp\'s apex, mimicking seborrheic dermatitis. Examination of the hair and scalp using fluorescence microscopy and fungal culture identified the presence of hyphae from Malassezia globosa, Malassezia furfur and Microsporum canis. The patient underwent with oral antifungal treatment for 3 months, resulting in the resolution of the rash and subsequent hair regrowth, with no recurrence during 6-month follow-up. In vitro co-culture experiments of Microsporum canis and Malassezia (both Malassezia globose and Malassezia furfur) revealed that Malassezia appears to facilitate Microsporum canis growth, while the reverse was not observed. This data suggests that Malassezia\'s use of long-chain fatty acids by might reduce its antibacterial effect, potentially aiding adult tinea capitis development caused by Microsporum canis.
摘要：
头癣,主要由毛癣菌和小孢子菌等皮肤癣菌引起，是一种影响头皮和头发的浅表真菌感染，常见于青春期前儿童，但罕见于成人。在这里，我们报告了一个成年女性头癣的独特病例，表现为头皮尖部弥漫性脱发和红斑炎症，模仿脂溢性皮炎.使用荧光显微镜和真菌培养物检查头发和头皮，确定了球形马拉色菌菌丝的存在，糠马拉色菌和犬小孢子菌。患者接受口服抗真菌药物治疗3个月，导致皮疹和随后的头发再生的解决，6个月随访期间无复发。犬小孢子菌和马拉色菌（球形马拉色菌和糠马拉色菌）的体外共培养实验表明，马拉色菌似乎促进犬小孢子菌的生长，而没有观察到相反的情况。这些数据表明，马拉色菌使用长链脂肪酸可能会降低其抗菌作用，可能有助于犬小孢子菌引起的成人头癣的发展。
