PDF(Pubmed)
Abstract：
Background: Primary malignant melanoma rarely occurs in the oral cavity. The tongue is a particularly unusual primary site; lesions may be pigmented or amelanotic. Primary malignant melanoma is frequently mistaken for squamous cell carcinoma. Case Report: A 27-year-old male presented with a large, painless, ulceroproliferative mass on the dorsal surface of the tongue for 6 months. Squamous cell carcinoma was suspected, and the lesion was biopsied. Histopathology was compatible with primary amelanotic malignant melanoma. The patient had no cutaneous lesions consistent with malignant melanoma, and no definitive metastatic lesions were found. Ultrasound and computed tomography did not reveal any evidence of regional draining lymph node metastasis or suspicious lesions anywhere else in the body. The patient underwent composite resection of the tongue tumor and bilateral neck lymph node dissection, had an uneventful postoperative recovery, but was lost to follow-up. Conclusion: Primary oral amelanotic malignant melanoma is a highly aggressive, potentially fatal tumor and because of its rarity, presents a diagnostic challenge. The ideal treatment modality for primary malignant melanoma of the tongue is poorly defined, but surgery is regarded as the most effective course of therapy.
摘要：
背景：原发性恶性黑色素瘤很少发生在口腔中。舌头是一个特别不寻常的原发部位；病变可能是色素沉着或色素性。原发性恶性黑色素瘤经常被误认为鳞状细胞癌。病例报告：一名27岁的男性，无痛,舌背表面的溃疡增生性肿块持续6个月。怀疑鳞状细胞癌,并对病变进行了活检。组织病理学与原发性无色素性恶性黑色素瘤兼容。患者没有与恶性黑色素瘤一致的皮肤病变，未发现明确的转移灶。超声和计算机断层扫描未发现任何局部引流淋巴结转移或身体其他部位可疑病变的证据。患者接受了舌癌复合切除术和双侧颈部淋巴结清扫术，术后恢复顺利，但失去了后续行动。结论：原发性口腔无色素性恶性黑色素瘤是一种高度侵袭性，潜在的致命肿瘤，因为它的稀有性，提出了诊断挑战。舌头原发性恶性黑色素瘤的理想治疗方式尚不明确，但是手术被认为是最有效的治疗方法。
