PDF(Pubmed)
Abstract：
Retinopathy of prematurity (ROP) is a retinopathy caused by abnormal proliferation of blood vessels in premature infants. It can lead to retinal detachment and, in severe cases, blindness, rendering ROP a critical condition. Advances in neonatal medicine have improved survival rates of low birth weight and low gestational age infants. However, this progress has also led to a rise in incidence of ROP. Currently, premature birth, low birth weight and high postpartum oxygen levels are independent risk factors for ROP. Other factors include mode of delivery, multiple births, anemia, blood transfusion, maternal pregnancy factors, neonatal bronchopulmonary dysplasia, use of surfactants, arterial ductus arteriosus and necrotizing enterocolitis. Laboratory indicators in premature infants such as platelet count, levels of blood glucose, inflammatory cells, lipid and hemoglobin and blood transfusion may also be associated with ROP. However, the etiology and pathogenesis of ROP are not fully understood. A number of factors may influence the onset and progression of ROP, including decreased platelet counts, decreased hemoglobin levels, increased white blood cell counts, increased blood glucose levels, and disorders of lipid metabolism. The present study reviewed the effects of platelet count, hemoglobin, blood glucose, inflammatory cells and factors, blood lipids, and plasma metabolic pathways on ROP.
摘要：
早产儿视网膜病变（ROP）是由早产儿血管异常增殖引起的视网膜病变。它可以导致视网膜脱离,在严重的情况下，失明,渲染ROP的临界条件。新生儿医学的进步提高了低出生体重和低胎龄婴儿的存活率。然而,这一进展也导致了ROP发病率的上升.目前,早产,低出生体重和高产后氧水平是ROP的独立危险因素。其他因素包括交付方式，多胎,贫血,输血,孕产妇怀孕因素，新生儿支气管肺发育不良,使用表面活性剂，动脉导管动脉和坏死性小肠结肠炎。早产儿的实验室指标，如血小板计数，血糖水平，炎症细胞，血脂、血红蛋白和输血也可能与ROP有关。然而,ROP的病因和发病机制尚不完全清楚。许多因素可能影响ROP的发生和进展，包括血小板计数减少,血红蛋白水平下降，白细胞计数增加,血糖水平升高，和脂质代谢紊乱。本研究综述了血小板计数的影响，血红蛋白,血糖，炎症细胞和因子，血脂,和血浆代谢途径对ROP的影响。
