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Abstract：
With the development of gene testing technology, we have found many different genes, and lncRNA is one of them. LncRNAs refer to a non-protein coding RNA molecule with a length of more than 200bp, which is one of the focuses of research on human malignant diseases such as LUAD. LncRNAs act as an oncogene or inhibitor to regulate the occurrence and progression of tumors. The differential expression of LncRNAs promotes or inhibits the progression of lung adenocarcinoma by affecting cell proliferation, metastasis, invasion, and apoptosis, thus affecting the prognosis and survival rate of patients. Therefore, LncRNAs can be used as a potential target for diagnosis and treatment of cancer. The early diagnosis of the disease was made through the detection of tumor markers. Because lung adenocarcinoma is not easy to diagnose in the early stage and tumor markers are easy to ignore, LncRNAs play an important role in the diagnosis and treatment of lung adenocarcinoma. The main purpose of this article is to summarize the known effects of LncRNAs on lung adenocarcinoma, the effect of differential expression of LncRNAs on the progression of lung adenocarcinoma, and related signal transduction pathways. And to provide a new idea for the future research of lung adenocarcinoma-related LncRNAs.
摘要：
随着基因检测技术的发展,我们发现了许多不同的基因，lncRNA就是其中之一。LncRNAs是指长度超过200bp的非蛋白质编码RNA分子。是LUAD等人类恶性疾病研究的重点之一。LncRNAs作为癌基因或抑制剂调节肿瘤的发生和进展。LncRNAs的差异表达通过影响细胞增殖促进或抑制肺腺癌的进展,转移,入侵,和细胞凋亡，从而影响患者的预后和生存率。因此,LncRNAs可以作为癌症诊断和治疗的潜在靶点。通过检测肿瘤标志物对该病进行早期诊断。由于肺腺癌早期不易诊断,肿瘤标志物容易忽视,LncRNAs在肺腺癌的诊断和治疗中起着重要作用。本文的主要目的是总结LncRNAs对肺腺癌的已知作用，LncRNAs差异表达对肺腺癌进展的影响,以及相关的信号转导通路。并为今后肺腺癌相关LncRNAs的研究提供新的思路。
