PDF(Pubmed)
Abstract：
UNASSIGNED: The aim is to study the various histopathological changes in the liver in pediatric patients with choledochal cyst (CC) and correlate with the presentation and type of cyst.
UNASSIGNED: In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst.
UNASSIGNED: All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients <1 years had 9/13 (69.2%) cystic variety and those >1 years had 17/17 (100%) fusiform variety of CC (P < 0.001). Patients <1 years frequently presented with jaundice and hepatomegaly and those >1 years presented with pain abdomen (P < 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (P < 0.001). However, no significant association was found with CHS and PI (P > 1.23).
UNASSIGNED: Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC <1 year presented frequently with jaundice, had the cystic type, and had a higher degree of liver damage on histopathology.
UNASSIGNED: In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst.
UNASSIGNED: All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients <1 years had 9/13 (69.2%) cystic variety and those >1 years had 17/17 (100%) fusiform variety of CC (P < 0.001). Patients <1 years frequently presented with jaundice and hepatomegaly and those >1 years presented with pain abdomen (P < 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (P < 0.001). However, no significant association was found with CHS and PI (P > 1.23).
UNASSIGNED: Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC <1 year presented frequently with jaundice, had the cystic type, and had a higher degree of liver damage on histopathology.
摘要：
■目的是研究小儿胆总管囊肿（CC）患者肝脏的各种组织病理学变化，并与囊肿的表现和类型相关。
■在一项包括所有接受CC切除的儿科患者的前瞻性观察研究中，胆汁淤积（CHS）形式的肝脏组织病理学变化，门静脉炎症（PI），胆管增生(BDP),使用评分系统对纤维化进行研究和分级。对它们进行了年龄分析，性别,症状,和囊肿的类型。
■所有30例CC患者均以CHS的形式在肝脏中表现出不同程度的组织病理学变化，PI,BDP,和肝纤维化。<1年的患者有9/13（69.2％）的囊性变种，>1年的患者有17/17（100％）的梭形变种CC（P<0.001）。<1年的患者常表现为黄疸和肝肿大，>1年的患者表现为腹痛（P<0.002）。与梭形变种相比，囊性变种的肝纤维化和BDP等级更高（P<0.001）。然而,与CHS和PI无显著相关性(P>1.23)。
■在所有CC患者中都可以看到不同等级的肝脏组织病理学变化。CC<1年的患者常出现黄疸，有囊性类型，在组织病理学上有较高程度的肝脏损害。
■在一项包括所有接受CC切除的儿科患者的前瞻性观察研究中，胆汁淤积（CHS）形式的肝脏组织病理学变化，门静脉炎症（PI），胆管增生(BDP),使用评分系统对纤维化进行研究和分级。对它们进行了年龄分析，性别,症状,和囊肿的类型。
■所有30例CC患者均以CHS的形式在肝脏中表现出不同程度的组织病理学变化，PI,BDP,和肝纤维化。<1年的患者有9/13（69.2％）的囊性变种，>1年的患者有17/17（100％）的梭形变种CC（P<0.001）。<1年的患者常表现为黄疸和肝肿大，>1年的患者表现为腹痛（P<0.002）。与梭形变种相比，囊性变种的肝纤维化和BDP等级更高（P<0.001）。然而,与CHS和PI无显著相关性(P>1.23)。
■在所有CC患者中都可以看到不同等级的肝脏组织病理学变化。CC<1年的患者常出现黄疸，有囊性类型，在组织病理学上有较高程度的肝脏损害。
