PDF(Pubmed)
Abstract：
UNASSIGNED: Closure of congenital body wall defects in children can be a challenging task for the pediatric Surgeon. Biological prosthesis has been increasingly used for high-risk wound closure in adult patients with excellent outcomes and use in the pediatric population has also been reported. Here, we aim to study the outcome of abdominal wound repair with a tissue-engineered acellular bovine pericardial patch.
UNASSIGNED: Over a period of 21 months, a total of 15 children had undergone abdominal wound repair with bioprostheses, i.e., bovine pericardial patch at our institute. Patient demographics, cause of defect, an indication of patch use, rate of infection, postoperative recovery, recurrence, and outcome were studied.
UNASSIGNED: A total of 15 patients underwent abdominal wall closure with acellular bovine pericardial patch. Nine out of 15 patients were neonates, of whom five had gastroschisis, two had a congenital diaphragmatic hernia, and two had ruptured omphalocele major. Of the rest 6 patients, 2 were patients of bladder exstrophy, 2 were older children of congenital diaphragmatic hernia with incisional hernias, and 2 were older children with omphalocele major. Out of the five patients with gastroschisis, two died during the early postoperative period due to sepsis. The wound healed in the rest 13 patients with mild skin dehiscence in two patients. Only one child had a recurrence.
UNASSIGNED: Reconstruction with acellular bovine pericardial patch is a viable option in children with high-risk abdominal wounds as it allows tensionless repair with excellent healing and minimal complications. Recurrence, if any, may disappear with time as remodeling of the prosthesis occurs along with the growth of the body wall of the child.
UNASSIGNED: Over a period of 21 months, a total of 15 children had undergone abdominal wound repair with bioprostheses, i.e., bovine pericardial patch at our institute. Patient demographics, cause of defect, an indication of patch use, rate of infection, postoperative recovery, recurrence, and outcome were studied.
UNASSIGNED: A total of 15 patients underwent abdominal wall closure with acellular bovine pericardial patch. Nine out of 15 patients were neonates, of whom five had gastroschisis, two had a congenital diaphragmatic hernia, and two had ruptured omphalocele major. Of the rest 6 patients, 2 were patients of bladder exstrophy, 2 were older children of congenital diaphragmatic hernia with incisional hernias, and 2 were older children with omphalocele major. Out of the five patients with gastroschisis, two died during the early postoperative period due to sepsis. The wound healed in the rest 13 patients with mild skin dehiscence in two patients. Only one child had a recurrence.
UNASSIGNED: Reconstruction with acellular bovine pericardial patch is a viable option in children with high-risk abdominal wounds as it allows tensionless repair with excellent healing and minimal complications. Recurrence, if any, may disappear with time as remodeling of the prosthesis occurs along with the growth of the body wall of the child.
摘要：
■关闭儿童的先天性体壁缺陷对儿科外科医生来说可能是一项具有挑战性的任务。生物假体已越来越多地用于成人患者的高风险伤口闭合，并在儿科人群中使用。这里,我们的目的是研究用组织工程的无细胞牛心包补片修复腹部伤口的效果。
■在21个月的时间里，共有15名儿童接受了生物假体腹部伤口修复，即，我们研究所的牛心包贴片。患者人口统计学，缺陷的原因，补丁使用的迹象，感染率，术后恢复,复发,和结果进行了研究。
■共有15例患者接受了无细胞牛心包补片的腹壁封闭。15名患者中有9名是新生儿，其中五个患有胃裂，两个人患有先天性膈疝,还有两个大脐膨出破裂。其余6名患者中,2人是膀胱外翻患者，2名患有先天性膈疝伴切口疝的大龄儿童，和2个是大龄儿童患有脐膨出。在五个腹裂患者中，其中2人在术后早期因脓毒症死亡.其余13例患者伤口愈合，2例患者皮肤轻度裂开。只有一个孩子复发了。
■无细胞牛心包补片重建是高危腹部创伤儿童的可行选择，因为它可以实现无张力修复，愈合良好，并发症少。复发,如果有的话,可能会随着时间的推移而消失，因为假体的重塑会随着儿童体壁的生长而发生。
■在21个月的时间里，共有15名儿童接受了生物假体腹部伤口修复，即，我们研究所的牛心包贴片。患者人口统计学，缺陷的原因，补丁使用的迹象，感染率，术后恢复,复发,和结果进行了研究。
■共有15例患者接受了无细胞牛心包补片的腹壁封闭。15名患者中有9名是新生儿，其中五个患有胃裂，两个人患有先天性膈疝,还有两个大脐膨出破裂。其余6名患者中,2人是膀胱外翻患者，2名患有先天性膈疝伴切口疝的大龄儿童，和2个是大龄儿童患有脐膨出。在五个腹裂患者中，其中2人在术后早期因脓毒症死亡.其余13例患者伤口愈合，2例患者皮肤轻度裂开。只有一个孩子复发了。
■无细胞牛心包补片重建是高危腹部创伤儿童的可行选择，因为它可以实现无张力修复，愈合良好，并发症少。复发,如果有的话,可能会随着时间的推移而消失，因为假体的重塑会随着儿童体壁的生长而发生。
