PDF(Pubmed)
Abstract：
UNASSIGNED: Bisphenol A (BPA) is an endocrine disrupter affecting glucose homeostasis.
UNASSIGNED: This study aimed to investigate BPA\'s relationship with Type 1 Diabetes Mellitus (T1DM) in Dakahlia Governorate\'s children, in Egypt.
UNASSIGNED: The study had two parts: clinical and experimental. Clinical Study was conducted on 200 children, equally divided into control and T1DM groups. They underwent: demographic data, height, weight, body mass index, glycosylated HbA1C, random blood glucose, and urinary BPA measurements. Experimental Study was conducted on 60 adult albino rats. Rats were randomly divided into three equal groups: control group: received 0.5 mL of pure olive oil, group 1: received 20 mg/kg/day BPA, and group 2: received 100 mg/kg/day BPA orally for 6 weeks. Fasting and two hours postprandial glucose levels were measured at the beginning and end of the study. Histopathological examination and imaging study of the pancreas were done.
UNASSIGNED: In clinical study: HbA1C and random blood glucose levels in diabetic children showed a significant increase compared to control. Children in control group showed controlled HbA1C, while the T1DM group showed 86% with poor diabetic control. There was a significant increase in BPA level in the T1DM group compared to the control. Rats that received BPA showed a marked increase in fasting and two hours postprandial glucose levels, histopathological changes in the pancreas with more changes determined in the high dose group, and a significant decrease in the islets of Langerhans diameters with group 2 more affected.
UNASSIGNED: So, BPA exposure could be considered a risk factor for T1DM in children.
UNASSIGNED: This study aimed to investigate BPA\'s relationship with Type 1 Diabetes Mellitus (T1DM) in Dakahlia Governorate\'s children, in Egypt.
UNASSIGNED: The study had two parts: clinical and experimental. Clinical Study was conducted on 200 children, equally divided into control and T1DM groups. They underwent: demographic data, height, weight, body mass index, glycosylated HbA1C, random blood glucose, and urinary BPA measurements. Experimental Study was conducted on 60 adult albino rats. Rats were randomly divided into three equal groups: control group: received 0.5 mL of pure olive oil, group 1: received 20 mg/kg/day BPA, and group 2: received 100 mg/kg/day BPA orally for 6 weeks. Fasting and two hours postprandial glucose levels were measured at the beginning and end of the study. Histopathological examination and imaging study of the pancreas were done.
UNASSIGNED: In clinical study: HbA1C and random blood glucose levels in diabetic children showed a significant increase compared to control. Children in control group showed controlled HbA1C, while the T1DM group showed 86% with poor diabetic control. There was a significant increase in BPA level in the T1DM group compared to the control. Rats that received BPA showed a marked increase in fasting and two hours postprandial glucose levels, histopathological changes in the pancreas with more changes determined in the high dose group, and a significant decrease in the islets of Langerhans diameters with group 2 more affected.
UNASSIGNED: So, BPA exposure could be considered a risk factor for T1DM in children.
摘要：
■双酚A（BPA）是一种影响葡萄糖稳态的内分泌干扰物。
■本研究旨在调查BPA与1型糖尿病（T1DM）的关系，在埃及。
■该研究分为两个部分：临床和实验。对200名儿童进行了临床研究，平均分为对照组和T1DM组。他们经历了：人口统计数据，高度,体重,身体质量指数,糖基化HbA1C，随机血糖，和尿BPA测量。对60只成年白化大鼠进行了实验研究。将大鼠随机分为3组：对照组：接受0.5mL纯橄榄油，组1：接受20mg/kg/天BPA，和第2组：口服100mg/kg/天的BPA，持续6周。在研究开始和结束时测量空腹和餐后两小时的葡萄糖水平。对胰腺进行组织病理学检查和影像学检查。
■在临床研究中：与对照组相比，糖尿病儿童的HbA1C和随机血糖水平显着增加。对照组患儿HbA1C控制,而T1DM组显示86％的糖尿病控制不佳。与对照组相比，T1DM组的BPA水平显着增加。接受BPA的大鼠显示空腹和餐后两小时血糖水平显著增加，胰腺的组织病理学变化，高剂量组的变化更多，胰岛的胰岛直径显着减少，第2组的影响更大。
■所以，BPA暴露可能是儿童T1DM的危险因素。
■本研究旨在调查BPA与1型糖尿病（T1DM）的关系，在埃及。
■该研究分为两个部分：临床和实验。对200名儿童进行了临床研究，平均分为对照组和T1DM组。他们经历了：人口统计数据，高度,体重,身体质量指数,糖基化HbA1C，随机血糖，和尿BPA测量。对60只成年白化大鼠进行了实验研究。将大鼠随机分为3组：对照组：接受0.5mL纯橄榄油，组1：接受20mg/kg/天BPA，和第2组：口服100mg/kg/天的BPA，持续6周。在研究开始和结束时测量空腹和餐后两小时的葡萄糖水平。对胰腺进行组织病理学检查和影像学检查。
■在临床研究中：与对照组相比，糖尿病儿童的HbA1C和随机血糖水平显着增加。对照组患儿HbA1C控制,而T1DM组显示86％的糖尿病控制不佳。与对照组相比，T1DM组的BPA水平显着增加。接受BPA的大鼠显示空腹和餐后两小时血糖水平显著增加，胰腺的组织病理学变化，高剂量组的变化更多，胰岛的胰岛直径显着减少，第2组的影响更大。
■所以，BPA暴露可能是儿童T1DM的危险因素。
