PDF(Pubmed)
Abstract：
UNASSIGNED: Early identification and treatment of non-alcoholic fatty liver disease (NAFLD) could reduce overall mortality. Anthropometric measurements offer a simple and cost-effective method to potentially improve early detection of NAFLD and prevent its complications. This study aims to estimate the prevalence of NAFLD using the fatty liver index (FLI) and evaluate the effectiveness of certain anthropometric measurements in predicting NAFLD as diagnosed by FLI.
UNASSIGNED: A cross-sectional analytical study was conducted with 1264 Saudi population without Type 2 diabetes mellitus (T2DM) non-alcoholic individuals at primary health care centers (PHCCs) in Jeddah city. Measurements included triglycerides, gamma-glutamyl transferase (GGT), glycated hemoglobin (HbA1c), and fasting plasma glucose (FPG). Measurements for neck circumference (NC), and calculations for weight-to-height ratio (WHtR) and weight-to-hip ratio (WHpR), along with FLI, were performed. NAFLD was identified in individuals with an FLI ⩾60. The receiver operating characteristic (ROC) curve analysis was utilized to assess the accuracy of WHtR, WHpR, and NC in detecting NAFLD, with Youden\'s index determining the optimal cutoff points for these 3 indices.
UNASSIGNED: The prevalence of NAFLD was found to be 30.9%. Among the markers, WHtR emerged as the most significant in indicating NAFLD, achieving an area under the curve (AUC) of 0.916; whereas NC and WHpR exhibited identical AUC values of 0.783. WHtR demonstrated superior diagnostic efficacy for identifying elevated FLI, with gender-specific cutoff values established at >0.57 for females and >0.61 for males. In all 3 markers, females exhibited higher sensitivity, specificity, and negative predictive value (NPV) compared to males.
UNASSIGNED: WHtR could serve as a useful tool in the initial clinical screening for NAFLD among Saudi population without T2DM to identify those who may benefit from more comprehensive testing. Further local studies are warranted to confirm the levels of accuracy and the calculated cutoffs.
UNASSIGNED: A cross-sectional analytical study was conducted with 1264 Saudi population without Type 2 diabetes mellitus (T2DM) non-alcoholic individuals at primary health care centers (PHCCs) in Jeddah city. Measurements included triglycerides, gamma-glutamyl transferase (GGT), glycated hemoglobin (HbA1c), and fasting plasma glucose (FPG). Measurements for neck circumference (NC), and calculations for weight-to-height ratio (WHtR) and weight-to-hip ratio (WHpR), along with FLI, were performed. NAFLD was identified in individuals with an FLI ⩾60. The receiver operating characteristic (ROC) curve analysis was utilized to assess the accuracy of WHtR, WHpR, and NC in detecting NAFLD, with Youden\'s index determining the optimal cutoff points for these 3 indices.
UNASSIGNED: The prevalence of NAFLD was found to be 30.9%. Among the markers, WHtR emerged as the most significant in indicating NAFLD, achieving an area under the curve (AUC) of 0.916; whereas NC and WHpR exhibited identical AUC values of 0.783. WHtR demonstrated superior diagnostic efficacy for identifying elevated FLI, with gender-specific cutoff values established at >0.57 for females and >0.61 for males. In all 3 markers, females exhibited higher sensitivity, specificity, and negative predictive value (NPV) compared to males.
UNASSIGNED: WHtR could serve as a useful tool in the initial clinical screening for NAFLD among Saudi population without T2DM to identify those who may benefit from more comprehensive testing. Further local studies are warranted to confirm the levels of accuracy and the calculated cutoffs.
摘要：
■非酒精性脂肪性肝病（NAFLD）的早期识别和治疗可以降低总死亡率。人体测量提供了一种简单且经济有效的方法，可以潜在地改善NAFLD的早期检测并预防其并发症。本研究旨在使用脂肪肝指数（FLI）估计NAFLD的患病率，并评估某些人体测量在预测FLI诊断的NAFLD中的有效性。
■在吉达市的初级卫生保健中心（PHCC）对1264名没有2型糖尿病（T2DM）的沙特人群进行了横断面分析研究。测量包括甘油三酯，γ-谷氨酰转移酶（GGT），糖化血红蛋白（HbA1c），空腹血糖（FPG）。测量颈围（NC），以及体重与身高比(WHtR)和体重与臀部比(WHpR)的计算，和FLI一起,被执行了。NAFLD是在FLI^60的个体中确定的。受试者工作特征(ROC)曲线分析用于评估WHtR的准确性，WHpR,和NC在检测NAFLD中，尤登指数确定了这3个指数的最佳截止点。
■NAFLD的患病率为30.9%。在标记中，WHtR在显示NAFLD方面是最重要的，曲线下面积(AUC)为0.916;而NC和WHpR显示相同的AUC值为0.783。WHtR在识别升高的FLI方面表现出优异的诊断功效，女性性别特异性临界值>0.57，男性>0.61。在所有3个标记中，女性表现出更高的敏感性，特异性，与男性相比，阴性预测值(NPV)。
■WHtR可以作为在没有T2DM的沙特人群中进行NAFLD初步临床筛查的有用工具，以确定可能从更全面的检测中受益的人群。需要进一步的本地研究来确认准确性水平和计算的截止值。
■在吉达市的初级卫生保健中心（PHCC）对1264名没有2型糖尿病（T2DM）的沙特人群进行了横断面分析研究。测量包括甘油三酯，γ-谷氨酰转移酶（GGT），糖化血红蛋白（HbA1c），空腹血糖（FPG）。测量颈围（NC），以及体重与身高比(WHtR)和体重与臀部比(WHpR)的计算，和FLI一起,被执行了。NAFLD是在FLI^60的个体中确定的。受试者工作特征(ROC)曲线分析用于评估WHtR的准确性，WHpR,和NC在检测NAFLD中，尤登指数确定了这3个指数的最佳截止点。
■NAFLD的患病率为30.9%。在标记中，WHtR在显示NAFLD方面是最重要的，曲线下面积(AUC)为0.916;而NC和WHpR显示相同的AUC值为0.783。WHtR在识别升高的FLI方面表现出优异的诊断功效，女性性别特异性临界值>0.57，男性>0.61。在所有3个标记中，女性表现出更高的敏感性，特异性，与男性相比，阴性预测值(NPV)。
■WHtR可以作为在没有T2DM的沙特人群中进行NAFLD初步临床筛查的有用工具，以确定可能从更全面的检测中受益的人群。需要进一步的本地研究来确认准确性水平和计算的截止值。
