PDF(Pubmed)
Abstract：
Human cytochrome P450 (CYP) enzymes are composed of 57 individual enzymes that perform monooxygenase activities. They have diverse physiological roles in metabolizing xenobiotics and producing important endogenous compounds, such as steroid hormones and vitamins. At least seven CYP enzymes are involved in steroid biosynthesis. Steroidogenesis primarily occurs in the adrenal glands and gonads, connecting each reaction to substrates and products. Steroids are essential for maintaining life and significantly contribute to sexual differentiation and reproductive functions within the body. Disorders in steroid biosynthesis can frequently cause serious health problems and lead to the development of diseases, such as prostate cancer, breast cancer, and Cushing\'s syndrome. In this review, we provide current updated knowledge on the major CYP enzymes involved in the biosynthetic process of steroids, with respect to their enzymatic mechanisms and clinical implications for the development of new drug candidates.
摘要：
人细胞色素P450(CYP)酶由执行单加氧酶活性的57种单独的酶组成。它们在代谢异源生物和产生重要的内源性化合物方面具有不同的生理作用，如类固醇激素和维生素。至少七种CYP酶参与类固醇生物合成。类固醇生成主要发生在肾上腺和性腺，将每个反应连接到底物和产物。类固醇对于维持生命至关重要，并显着有助于体内的性分化和生殖功能。类固醇生物合成疾病经常会导致严重的健康问题，并导致疾病的发展。比如前列腺癌，乳腺癌,和库欣综合征。在这次审查中,我们提供有关类固醇生物合成过程中涉及的主要CYP酶的最新知识，关于它们的酶促机制和对开发新候选药物的临床意义。
