A case of chronic progressive autoimmune GFAP astrocytopathy with extensive meningoencephalomyelitis and contrast enhancement on MRI.

慢性进行性自身免疫性 GFAP 星形细胞病伴广泛脑膜脑脊髓炎和 MRI 对比增强 1 例。

• 发表时间: 2024 Jun
• 来源期刊: eNeurologicalSci
• DOI: 10.1016/j.ensci.2024.100507
• PMID: 38911509
• 文章类型: Journal Article
• 作者列表: Oka H,Nakamura T,Sugawara T,Ishizawa K,Amari M,Kawarabayashi T,Okamoto K,Takatama M,Nakata S,Yoshimoto Y,Yamazaki A,Yokoo H,Kimura A,Shimohata T,Ikeda Y,Shoji M

关键词: Autoimmune GFAP astrocytopathy; Chronic progressive meningoencephalomyelitis; Extensive perivascular gadolinium enhancement; Intravenous immunoglobulin; Intravenous methylprednisolone

Abstract

•We herein present a case of chronic progressive autoimmune GFAP astrocytopathy.•Symmetrical high-intensity signals on FLAIR were observed in the white matter of the temporal and occipital lobes, lateral cerebral ventricle walls, hippocampus, amygdala, and occipital cortex, with extensive Gd enhancement in radial perivascular lesions and the ependyma in the choroid plexus.•Improvements were achieved by 4 courses of IVMP and one of IVIg.

摘要

•我们在此介绍一例慢性进行性自身免疫性GFAP星形细胞病。•在颞叶和枕叶白质中观察到FLAIR上的对称高强度信号，侧脑室壁，海马体,杏仁核,和枕骨皮质,放射状血管周围病变和脉络丛室管膜广泛Gd增强。•通过4个IVMP课程和一个IVIg课程实现了改进。