PDF(Pubmed)
Abstract：
UNASSIGNED: Coronavirus disease (COVID-19) may trigger the reactivation of the latent varicella-zoster virus and may be a risk factor for herpes zoster (HZ). However, the causal relationship between COVID-19 and varicella-zoster infections remains controversial. This study aimed to estimate the causal inferences between COVID-19 and HZ.
UNASSIGNED: This study used a two-sample Mendelian randomization (MR) design. The inverse variance-weighted method was used as the primary method and sensitivity analyses were conducted, including the MR-Egger regression, weighted median and weighted mode. We searched at https://gwas.mrcieu.ac.uk/ using the keywords \"COVID-19\" for exposure data and \"zoster\" for outcome datasets.
UNASSIGNED: We got 26 COVID-19 datasets and five zoster datasets. We used 26 COVID-19 datasets as exposure data corresponding to each zoster dataset for the MR analysis. There were nine datasets of COVID-19 where the number of SNPs was fewer than three in the MR analysis of the risk of HZ, varicella zoster virus (VZV) glycoprotein E and I antibody levels, anti-VZV IgG seropositivity, and post-zoster neuralgia. In addition, there were 10 datasets of COVID-19 where the number of SNPs was less than three in the MR analysis of anti-VZV IgG levels. The results of the MR analysis showed that all p-values were greater than 0.05. Sensitivity analysis revealed no evidence of horizontal pleiotropy in most two sample MR analyses.
UNASSIGNED: Our results indicate that there is no causal relationship between COVID-19 and varicella-zoster infection, HZ progression, and postherpetic neuralgia.
UNASSIGNED: This study used a two-sample Mendelian randomization (MR) design. The inverse variance-weighted method was used as the primary method and sensitivity analyses were conducted, including the MR-Egger regression, weighted median and weighted mode. We searched at https://gwas.mrcieu.ac.uk/ using the keywords \"COVID-19\" for exposure data and \"zoster\" for outcome datasets.
UNASSIGNED: We got 26 COVID-19 datasets and five zoster datasets. We used 26 COVID-19 datasets as exposure data corresponding to each zoster dataset for the MR analysis. There were nine datasets of COVID-19 where the number of SNPs was fewer than three in the MR analysis of the risk of HZ, varicella zoster virus (VZV) glycoprotein E and I antibody levels, anti-VZV IgG seropositivity, and post-zoster neuralgia. In addition, there were 10 datasets of COVID-19 where the number of SNPs was less than three in the MR analysis of anti-VZV IgG levels. The results of the MR analysis showed that all p-values were greater than 0.05. Sensitivity analysis revealed no evidence of horizontal pleiotropy in most two sample MR analyses.
UNASSIGNED: Our results indicate that there is no causal relationship between COVID-19 and varicella-zoster infection, HZ progression, and postherpetic neuralgia.
摘要：
■冠状病毒病（COVID-19）可能引发潜伏水痘-带状疱疹病毒的重新激活，并且可能是带状疱疹（HZ）的危险因素。然而,COVID-19与水痘-带状疱疹感染之间的因果关系仍存在争议.本研究旨在估计COVID-19和HZ之间的因果关系。
■本研究采用双样本孟德尔随机化（MR）设计。采用逆方差加权法作为主要方法,进行了敏感性分析,包括MR-Egger回归，加权中位数和加权模式。我们在https://gwas搜索。mrcieu.AC.英国/使用关键词“COVID-19”表示暴露数据，使用关键词“zoster”表示结果数据集。
■我们获得了26个COVID-19数据集和5个带状疱疹数据集。我们使用26个COVID-19数据集作为与每个带状疱疹数据集相对应的暴露数据，用于MR分析。有9个COVID-19数据集，在对HZ风险的MR分析中，SNP的数量少于3个，水痘带状疱疹病毒（VZV）糖蛋白E和I抗体水平，抗VZVIgG血清阳性，和带状疱疹后神经痛。此外,在抗VZVIgG水平的MR分析中，有10个COVID-19数据集的SNP数量少于3个。MR分析结果显示,所有p值均大于0.05。敏感性分析显示，在大多数两个样品MR分析中，没有水平多效性的证据。
■我们的结果表明，COVID-19与水痘-带状疱疹感染之间没有因果关系，HZ进展，和带状疱疹后神经痛.
■本研究采用双样本孟德尔随机化（MR）设计。采用逆方差加权法作为主要方法,进行了敏感性分析,包括MR-Egger回归，加权中位数和加权模式。我们在https://gwas搜索。mrcieu.AC.英国/使用关键词“COVID-19”表示暴露数据，使用关键词“zoster”表示结果数据集。
■我们获得了26个COVID-19数据集和5个带状疱疹数据集。我们使用26个COVID-19数据集作为与每个带状疱疹数据集相对应的暴露数据，用于MR分析。有9个COVID-19数据集，在对HZ风险的MR分析中，SNP的数量少于3个，水痘带状疱疹病毒（VZV）糖蛋白E和I抗体水平，抗VZVIgG血清阳性，和带状疱疹后神经痛。此外,在抗VZVIgG水平的MR分析中，有10个COVID-19数据集的SNP数量少于3个。MR分析结果显示,所有p值均大于0.05。敏感性分析显示，在大多数两个样品MR分析中，没有水平多效性的证据。
■我们的结果表明，COVID-19与水痘-带状疱疹感染之间没有因果关系，HZ进展，和带状疱疹后神经痛.
