PDF(Pubmed)
Abstract：
Parkinson\'s disease (PD), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic nerve terminals in the striatum with deficit of dopamine. To date the mechanisms sustaining PD pathogenesis are under investigation; however, a solid body of experimental evidence involves neuroinflammation, mitochondrial dysfunction, oxidative stress, and apoptotic cell death as the crucial factors operating in the pathogenesis of PD. Nutrition is known to modulate neuroinflammatory processes implicated in the pathogenesis and progression of this neurodegenerative disorder. Consistent with this notion, the Burseraceae family, which includes the genera Boswellia and Commiphora, are attracting emerging interest in the treatment of a wide range of pathological conditions, including neuroinflammation and cognitive decline. Bioactive components present in these species have been shown to improve cognitive function and to protect neurons from degeneration in in vitro, animal, as well as clinical research. These effects are mediated through the anti-inflammatory, antiamyloidogenic, anti-apoptotic, and antioxidative properties of bioactive components. Although many studies have exploited possible therapeutic approaches, data from human studies are lacking and their neuroprotective potential makes them a promising option for preventing and treating major neurodegenerative disorders.
摘要：
帕金森病（PD），以震颤为特征，运动缓慢，刚度,和糟糕的平衡，是由于黑质致密部和纹状体多巴胺能神经末梢的多巴胺能神经元大量丢失，多巴胺不足。迄今为止，维持PD发病机理的机制正在研究中；然而，大量的实验证据涉及神经炎症，线粒体功能障碍，氧化应激，凋亡细胞死亡是PD发病的关键因素。已知营养调节与这种神经退行性疾病的发病机理和进展有关的神经炎症过程。与这个概念一致，卷子科，其中包括Boswellia和Commiphora属，正在吸引人们对治疗各种病理疾病的兴趣，包括神经炎症和认知功能下降。这些物种中存在的生物活性成分已被证明可以改善认知功能并保护神经元免受体外变性，动物,以及临床研究。这些作用是通过抗炎，抗淀粉样蛋白，抗凋亡，和生物活性成分的抗氧化性能。尽管许多研究已经利用了可能的治疗方法，缺乏人类研究的数据，它们的神经保护潜力使它们成为预防和治疗主要神经退行性疾病的有希望的选择。
