PDF(Pubmed)
Abstract：
Valproate encephalopathy is one of the unusual and severe but treatable side effect. This research focuses on four female patients who had valproate medication for epilepsy and developed an increased frequency of seizures, exacerbated disruption of consciousness, gastrointestinal problems, cognitive dysfunction, ataxia, and psychobehavioral abnormalities. The patient\'s symptoms improved over time once sodium valproate was stopped. As a result, when using sodium valproate, one should be aware of the risk of sodium valproate encephalopathy and cease using the medication right once if any of the above symptoms of unknown etiology manifest clinically. We also go over the potential pathogenesis that lead to valproate encephalopathy and the heightened risk of encephalopathy from taking antiepileptic medications together. It was stressed how crucial it is to identify, diagnose, and treat sodium valproate encephalopathy as soon as possible.
摘要：
丙戊酸脑病是一种罕见且严重但可治疗的副作用。这项研究的重点是四名女性患者，他们服用了丙戊酸药物治疗癫痫，并增加了癫痫发作的频率，加剧了意识的破坏，肠胃问题,认知功能障碍，共济失调,和心理行为异常。停用丙戊酸钠后，患者症状随时间改善。因此,使用丙戊酸钠时，人们应该意识到丙戊酸钠脑病的风险，如果任何上述病因不明的症状在临床上表现出来，就停止使用药物。我们还研究了导致丙戊酸脑病的潜在发病机制，以及一起服用抗癫痫药物会增加脑病的风险。有人强调，确定是多么重要，诊断,并尽快治疗丙戊酸钠脑病。
