PDF(Pubmed)
Abstract：
UNASSIGNED: Biochemical blood testing is the main diagnostic indicator of the clinical condition of highly productive animals and a method of determining changes in metabolic disorders. This study focuses on metabolic changes (ketosis), which are of the utmost importance in the assessment of the health status of animals, as well as differences in intergroup characteristics. The main focus of this study is to demonstrate the influence of subclinical ketosis in highly productive cows on changes in biochemical blood parameters during different physiological periods to further prevent this disease, adjust feeding rations, and prevent premature culling of animals. This study aimed to evaluate and establish changes in the biochemical status dynamics of highly productive cows with metabolic disorders in an industrial livestock complex.
UNASSIGNED: Blood samples were systematically collected from highly productive cows of the Simmental breed (n = 60) and served as the primary material for subsequent analyses. Each methodological step was designed to ensure evaluation of the metabolic changes associated with post-calving adjustments in highly productive dairy cows. This study employed a comprehensive approach integrating clinical assessments, laboratory analyses, biochemical evaluations, instrumental measurements, and statistical analyses.
UNASSIGNED: A biochemical blood test showed that the number of ketone bodies in the experimental group exceeded the norm, varied depending on the physiological state of the animals, and ranged from 0.89 to 1.45 mmol/L. At 10 days after calving, the highest indicator was 1.45 ± 0.05 mmol/L. This indicator was 1.05 mmol/L higher than that in the control group and exceeded the norm by 0.95.
UNASSIGNED: Excess ketone bodies in the blood of animals led to accumulation in urine and milk, indicating a disturbance in metabolic processes in the body and a decrease in the quality of animal husbandry products. The sample size and the focus on a single breed from one geographical location may limit the generalizability of the findings. Further research should explore the mechanistic bases of ketosis development, potentially integrating genomic and proteomic approaches to understand the genetic predispositions and molecular pathways involved.
UNASSIGNED: Blood samples were systematically collected from highly productive cows of the Simmental breed (n = 60) and served as the primary material for subsequent analyses. Each methodological step was designed to ensure evaluation of the metabolic changes associated with post-calving adjustments in highly productive dairy cows. This study employed a comprehensive approach integrating clinical assessments, laboratory analyses, biochemical evaluations, instrumental measurements, and statistical analyses.
UNASSIGNED: A biochemical blood test showed that the number of ketone bodies in the experimental group exceeded the norm, varied depending on the physiological state of the animals, and ranged from 0.89 to 1.45 mmol/L. At 10 days after calving, the highest indicator was 1.45 ± 0.05 mmol/L. This indicator was 1.05 mmol/L higher than that in the control group and exceeded the norm by 0.95.
UNASSIGNED: Excess ketone bodies in the blood of animals led to accumulation in urine and milk, indicating a disturbance in metabolic processes in the body and a decrease in the quality of animal husbandry products. The sample size and the focus on a single breed from one geographical location may limit the generalizability of the findings. Further research should explore the mechanistic bases of ketosis development, potentially integrating genomic and proteomic approaches to understand the genetic predispositions and molecular pathways involved.
摘要：
■生化血液检测是高产动物临床状况的主要诊断指标，是确定代谢紊乱变化的一种方法。这项研究的重点是代谢变化（酮症），这对评估动物的健康状况至关重要，以及群体间特征的差异。这项研究的主要重点是证明高产量奶牛亚临床酮症对不同生理时期生化血液参数变化的影响，以进一步预防这种疾病，调整喂食口粮，并防止过早扑杀动物。这项研究旨在评估和建立在工业牲畜综合体中代谢紊乱的高产奶牛的生化状态动力学变化。
从西门塔尔品种的高产奶牛(n=60)系统地收集血液样品,并用作后续分析的主要材料。设计每个方法步骤以确保评估与高产奶牛产卵后调整相关的代谢变化。本研究采用了综合临床评估的综合方法，实验室分析,生化评价,仪器测量，和统计分析。
■一项生化血液检查显示，实验组酮体数量超过常值，根据动物的生理状态而变化，范围为0.89至1.45mmol/L产牛10天后，最高指标为1.45±0.05mmol/L该指标比对照组高1.05mmol/L，超出常规0.95。
■动物血液中过多的酮体导致尿液和乳汁积聚，表明体内代谢过程受到干扰，畜牧业产品质量下降。样本量和对一个地理位置的单一品种的关注可能会限制发现的普遍性。进一步的研究应探索酮症发展的机制基础，可能整合基因组和蛋白质组学方法来了解所涉及的遗传易感性和分子途径。
从西门塔尔品种的高产奶牛(n=60)系统地收集血液样品,并用作后续分析的主要材料。设计每个方法步骤以确保评估与高产奶牛产卵后调整相关的代谢变化。本研究采用了综合临床评估的综合方法，实验室分析,生化评价,仪器测量，和统计分析。
■一项生化血液检查显示，实验组酮体数量超过常值，根据动物的生理状态而变化，范围为0.89至1.45mmol/L产牛10天后，最高指标为1.45±0.05mmol/L该指标比对照组高1.05mmol/L，超出常规0.95。
■动物血液中过多的酮体导致尿液和乳汁积聚，表明体内代谢过程受到干扰，畜牧业产品质量下降。样本量和对一个地理位置的单一品种的关注可能会限制发现的普遍性。进一步的研究应探索酮症发展的机制基础，可能整合基因组和蛋白质组学方法来了解所涉及的遗传易感性和分子途径。
