PDF(Pubmed)
Abstract：
UNASSIGNED: This meta-analysis examines peak systolic velocities (PSVs) in thyroid arteries as potential biomarkers for thyroid disorders, which includes treated and untreated Graves\' disease(GD) and destructive thyrotoxicosis(DT).
UNASSIGNED: A search across databases including PubMed, Google Scholar, Embase, and Web of Science identified studies assessing peak systolic flow velocity in the inferior thyroid artery (ITA-PSV) and superior thyroid artery (STA-PSV) diagnostic efficacy in GD and DT.And the search was restricted to publications in the English language.The analysis compared STA-PSV and ITA-PSV across patient groups, evaluating intra-group variances and synthesizing sensitivity and specificity data.
UNASSIGNED: The analysis covered 18 studies with 1276 GD, 564 DT patients, and 544 controls. The difference of STA-PSV between GD group, DT group and normal group and the difference of ITA-PSV were analyzed in subgroups, and there was no statistical significance between subgroups when comparing any two groups. Normal subjects displayed intra-group ITA-PSV and STA-PSV differences with established cut-off values of 20.33 cm/s (95% CI, 17.48-23.18) for ITA-PSV and 25.61 cm/s (95% CI, 20.37-30.85) for STA-PSV. However, no significant intra-group differences were observed in the STA-PSV and ITA-PSV cut-off values among groups with GD or DT. The combined cut-off values for these patient groups and normal subjects were 68.63 cm/s (95% CI, 59.12-78.13), 32.08 cm/s (95% CI, 25.90-38.27), and 23.18 cm/s (95% CI, 20.09-26.28), respectively. The diagnostic odds ratio(DOR) for these values was 35.86 (95% CI, 18.21-70.60), and the area under the summary receiver operating characteristic (SROC) curve was 0.91, with a sensitivity estimate of 0.842 (95% CI, 0.772-0.866).
UNASSIGNED: PSVs in thyroid arteries are useful diagnostic tools in distinguishing DT from GD. A PSV above 68.63 cm/s significantly improves GD diagnosis with up to 91% efficacy. No notable differences were found between superior and inferior thyroid arteries in these conditions.
UNASSIGNED: A search across databases including PubMed, Google Scholar, Embase, and Web of Science identified studies assessing peak systolic flow velocity in the inferior thyroid artery (ITA-PSV) and superior thyroid artery (STA-PSV) diagnostic efficacy in GD and DT.And the search was restricted to publications in the English language.The analysis compared STA-PSV and ITA-PSV across patient groups, evaluating intra-group variances and synthesizing sensitivity and specificity data.
UNASSIGNED: The analysis covered 18 studies with 1276 GD, 564 DT patients, and 544 controls. The difference of STA-PSV between GD group, DT group and normal group and the difference of ITA-PSV were analyzed in subgroups, and there was no statistical significance between subgroups when comparing any two groups. Normal subjects displayed intra-group ITA-PSV and STA-PSV differences with established cut-off values of 20.33 cm/s (95% CI, 17.48-23.18) for ITA-PSV and 25.61 cm/s (95% CI, 20.37-30.85) for STA-PSV. However, no significant intra-group differences were observed in the STA-PSV and ITA-PSV cut-off values among groups with GD or DT. The combined cut-off values for these patient groups and normal subjects were 68.63 cm/s (95% CI, 59.12-78.13), 32.08 cm/s (95% CI, 25.90-38.27), and 23.18 cm/s (95% CI, 20.09-26.28), respectively. The diagnostic odds ratio(DOR) for these values was 35.86 (95% CI, 18.21-70.60), and the area under the summary receiver operating characteristic (SROC) curve was 0.91, with a sensitivity estimate of 0.842 (95% CI, 0.772-0.866).
UNASSIGNED: PSVs in thyroid arteries are useful diagnostic tools in distinguishing DT from GD. A PSV above 68.63 cm/s significantly improves GD diagnosis with up to 91% efficacy. No notable differences were found between superior and inferior thyroid arteries in these conditions.
摘要：
■这项荟萃分析检查了甲状腺动脉的收缩期峰值速度（PSV）作为甲状腺疾病的潜在生物标志物，包括治疗和未治疗的Graves病(GD)和破坏性甲状腺毒症(DT)。
■跨数据库搜索，包括PubMed，谷歌学者，Embase,和WebofScience确定了评估甲状腺下动脉（ITA-PSV）和甲状腺上动脉（STA-PSV）在GD和DT中诊断功效的收缩期峰值流速的研究。搜索仅限于英语出版物。该分析比较了患者组的STA-PSV和ITA-PSV，评估组内差异并综合敏感性和特异性数据。
■该分析涵盖了18项研究，其中有1276个GD，564名DT患者，和544个控件。GD组之间STA-PSV的差异，分析DT组与正常组及各亚组ITA-PSV的差异,与任何两组相比，亚组之间无统计学意义。正常受试者显示出组内ITA-PSV和STA-PSV差异，ITA-PSV的确定临界值为20.33cm/s（95％CI，17.48-23.18），STA-PSV的确定临界值为25.61cm/s（95％CI，20.37-30.85）。然而,GD或DT组的STA-PSV和ITA-PSV截止值没有观察到显著的组内差异.这些患者组和正常受试者的联合临界值为68.63cm/s（95％CI，59.12-78.13），32.08厘米/秒（95%CI，25.90-38.27），和23.18cm/s（95%CI，20.09-26.28），分别。这些值的诊断比值比（DOR）为35.86（95％CI，18.21-70.60），摘要接受者工作特征(SROC)曲线下面积为0.91,敏感性估计值为0.842(95%CI,0.772-0.866).
■甲状腺动脉中的PSV是区分DT和GD的有用诊断工具。高于68.63cm/s的PSV显着改善GD诊断，功效高达91％。在这些情况下，甲状腺上动脉和下动脉之间没有发现显着差异。
■跨数据库搜索，包括PubMed，谷歌学者，Embase,和WebofScience确定了评估甲状腺下动脉（ITA-PSV）和甲状腺上动脉（STA-PSV）在GD和DT中诊断功效的收缩期峰值流速的研究。搜索仅限于英语出版物。该分析比较了患者组的STA-PSV和ITA-PSV，评估组内差异并综合敏感性和特异性数据。
■该分析涵盖了18项研究，其中有1276个GD，564名DT患者，和544个控件。GD组之间STA-PSV的差异，分析DT组与正常组及各亚组ITA-PSV的差异,与任何两组相比，亚组之间无统计学意义。正常受试者显示出组内ITA-PSV和STA-PSV差异，ITA-PSV的确定临界值为20.33cm/s（95％CI，17.48-23.18），STA-PSV的确定临界值为25.61cm/s（95％CI，20.37-30.85）。然而,GD或DT组的STA-PSV和ITA-PSV截止值没有观察到显著的组内差异.这些患者组和正常受试者的联合临界值为68.63cm/s（95％CI，59.12-78.13），32.08厘米/秒（95%CI，25.90-38.27），和23.18cm/s（95%CI，20.09-26.28），分别。这些值的诊断比值比（DOR）为35.86（95％CI，18.21-70.60），摘要接受者工作特征(SROC)曲线下面积为0.91,敏感性估计值为0.842(95%CI,0.772-0.866).
■甲状腺动脉中的PSV是区分DT和GD的有用诊断工具。高于68.63cm/s的PSV显着改善GD诊断，功效高达91％。在这些情况下，甲状腺上动脉和下动脉之间没有发现显着差异。
