PDF(Pubmed)
Abstract：
The fundamental conception of delirium is altered arousal. In addition, sleep-wake cycle isturbances including insomnia, excessive daytime napping, and disintegration of the xpected circadian patterns have been described as a characteristic component of delirium or decades, and demonstrated to be a core symptom domain of delirium. Although on-pharmacological interventions are successful to some extent, they have limitations due o various biological etiologies for delirium. Among pharmacological interventions, ntipsychotics seem to be effective, but they are not suitable for preventive use because f relatively frequent side-effects such as extrapyramidal symptoms. Recently, new type of rugs for insomnia have been focused with respect to delirium prevention. Recent eta-analyses show effectiveness of melatonin receptor agonists and orexin receptor ntagonists for delirium prevention, and real-world data support them.
摘要：
谵妄的基本概念是唤醒改变。此外,睡眠-觉醒周期失调，包括失眠，白天午睡过多，和Xpected昼夜节律模式的解体已被描述为谵妄或几十年的特征成分，并被证明是谵妄的核心症状领域。虽然药物干预在某种程度上是成功的，由于谵妄的各种生物学病因，它们有局限性。在药物干预措施中，精神病药物似乎很有效，但它们不适合预防性使用，因为副作用相对频繁，如锥体外系症状。最近,新型的失眠地毯已集中在预防谵妄方面。最近的eta分析显示，褪黑激素受体激动剂和食欲素受体ntstars激动剂预防谵妄的有效性，和现实世界的数据支持他们。
