PDF(Pubmed)
Abstract：
UNASSIGNED: The prevalence of obesity continues to rise. People with obesity are at increased risk of several diseases. We tested an algorithm-based screening program for people with a BMI above 30 kg/m2 and present data on the prevalence of previously undiagnosed obesity-related diseases.
UNASSIGNED: Seven hundred and sixty-nine persons with BMI > 30 kg/m2 and age 18-60 years were screened for diabetes (assessed by glycosylated hemoglobin and oral glucose tolerance test at HbA1c 43-48 mmol/mol), sleep apnea (screened by questionnaires and assessed by cardiorespiratory monitoring at indication of sleep disorder), liver steatosis or liver fibrosis (assessed by biochemistry and fibroscan) and arterial hypertension (assessed by both office and 24-hour blood pressure measurement). A reference group of people with a BMI of 18.5-29.9 kg/m2 was established.
UNASSIGNED: Of those referred, 73.0% were women. We identified new diabetes in 4.2%, prediabetes in 9.1%, moderate-to-severe sleep apnea in 25.1%, increased liver fat and increased liver stiffness in 68.1% and 17.4%, respectively, and hypertension or masked hypertension in 19.0%. The prevalence of diseases was much higher among men and increased with BMI. Except for hypertension, we found few participants with undiagnosed disease in the reference group.
UNASSIGNED: An algorithm-based screening program is feasible and reveals undiagnosed obesity-related disease in a large proportion of the participants. The disproportional referral pattern calls for a tailored approach aiming to include more men with obesity.
UNASSIGNED: Inclusion of the non-obese group was approved by the Scientific Ethics Committee of The Region of Southern Denmark (project identification number: S-20210091), and the study was reported at clinicaltrials.gov (NCT05176132).
The number of people with obesity is going up, and they are at a higher risk for various diseases. We tested a screening program for people referred with a BMI over 30 kg/m2 and presented the prevalence of diseases related to obesity. We screened 769 people aged 18 to 60 years with a BMI over 30 kg/m2 for diabetes (biochemistry and glucose tolerance test), sleep apnea (both questionnaires and home monitoring), liver disease (biochemistry and liver scan) and high blood pressure (office and 24-hour readings). We also tested a reference group of people with BMI 18.5-30 kg/m2. Among those screened, 73.0% were women. We found new cases of diabetes in 4.2%, prediabetes in 9.1%, sleep apnea in 25.1%, increased liver fat in 68.1%, increased liver stiffness in 17.4%, and hypertension or masked hypertension in 19.0%. The diseases were more common in men and increased with both higher BMI and age. Except for hypertension, we found few cases in the reference groups. The screening program uncovered undiagnosed obesity-related diseases in a large group of individuals. The uneven distribution of referrals suggests we need a customized approach to include more men with obesity.
UNASSIGNED: Seven hundred and sixty-nine persons with BMI > 30 kg/m2 and age 18-60 years were screened for diabetes (assessed by glycosylated hemoglobin and oral glucose tolerance test at HbA1c 43-48 mmol/mol), sleep apnea (screened by questionnaires and assessed by cardiorespiratory monitoring at indication of sleep disorder), liver steatosis or liver fibrosis (assessed by biochemistry and fibroscan) and arterial hypertension (assessed by both office and 24-hour blood pressure measurement). A reference group of people with a BMI of 18.5-29.9 kg/m2 was established.
UNASSIGNED: Of those referred, 73.0% were women. We identified new diabetes in 4.2%, prediabetes in 9.1%, moderate-to-severe sleep apnea in 25.1%, increased liver fat and increased liver stiffness in 68.1% and 17.4%, respectively, and hypertension or masked hypertension in 19.0%. The prevalence of diseases was much higher among men and increased with BMI. Except for hypertension, we found few participants with undiagnosed disease in the reference group.
UNASSIGNED: An algorithm-based screening program is feasible and reveals undiagnosed obesity-related disease in a large proportion of the participants. The disproportional referral pattern calls for a tailored approach aiming to include more men with obesity.
UNASSIGNED: Inclusion of the non-obese group was approved by the Scientific Ethics Committee of The Region of Southern Denmark (project identification number: S-20210091), and the study was reported at clinicaltrials.gov (NCT05176132).
The number of people with obesity is going up, and they are at a higher risk for various diseases. We tested a screening program for people referred with a BMI over 30 kg/m2 and presented the prevalence of diseases related to obesity. We screened 769 people aged 18 to 60 years with a BMI over 30 kg/m2 for diabetes (biochemistry and glucose tolerance test), sleep apnea (both questionnaires and home monitoring), liver disease (biochemistry and liver scan) and high blood pressure (office and 24-hour readings). We also tested a reference group of people with BMI 18.5-30 kg/m2. Among those screened, 73.0% were women. We found new cases of diabetes in 4.2%, prediabetes in 9.1%, sleep apnea in 25.1%, increased liver fat in 68.1%, increased liver stiffness in 17.4%, and hypertension or masked hypertension in 19.0%. The diseases were more common in men and increased with both higher BMI and age. Except for hypertension, we found few cases in the reference groups. The screening program uncovered undiagnosed obesity-related diseases in a large group of individuals. The uneven distribution of referrals suggests we need a customized approach to include more men with obesity.
摘要：
■肥胖的患病率持续上升。肥胖患者患几种疾病的风险增加。我们对BMI超过30kg/m2的人群进行了基于算法的筛查程序，并提供了有关先前未诊断的肥胖相关疾病患病率的数据。
■769名BMI>30kg/m2且年龄18-60岁的人进行了糖尿病筛查（通过糖化血红蛋白和HbA1c43-48mmol/mol的口服葡萄糖耐量试验进行评估），睡眠呼吸暂停（通过问卷调查筛查，并通过心肺监测评估睡眠障碍的迹象），肝脂肪变性或肝纤维化（通过生物化学和纤维扫描评估）和动脉高血压（通过办公室和24小时血压测量评估）。建立了BMI为18.5-29.9kg/m2的参考人群。
■在提到的那些中，73.0%是女性。我们发现了4.2%的新糖尿病，糖尿病前期占9.1%，25.1％的中度至重度睡眠呼吸暂停，增加肝脏脂肪和增加肝脏硬度68.1％和17.4％，分别,而高血压或隐性高血压占19.0%。男性的疾病患病率更高，并且随着BMI的增加而增加。除了高血压,在参照组中,我们发现少数参与者患有未确诊的疾病.
■基于算法的筛查程序是可行的，并且在很大一部分参与者中揭示了未诊断的肥胖相关疾病。不成比例的转诊模式需要一种量身定制的方法，旨在包括更多的肥胖男性。
■非肥胖组由丹麦南部地区科学伦理委员会批准（项目识别号：S-20210091），该研究发表在clinicaltrials.gov（NCT05176132）。
肥胖的人数正在上升,他们患各种疾病的风险更高。我们测试了一项针对BMI超过30kg/m2的人群的筛查计划，并介绍了与肥胖相关的疾病的患病率。我们筛查了769名年龄在18至60岁、BMI超过30kg/m2的糖尿病患者（生物化学和葡萄糖耐量试验），睡眠呼吸暂停（问卷调查和家庭监测），肝病（生物化学和肝脏扫描）和高血压（办公室和24小时读数）。我们还测试了BMI为18.5-30kg/m2的参考人群。在那些被筛选的人中，73.0%是女性。我们发现4.2%的新糖尿病病例，糖尿病前期占9.1%，睡眠呼吸暂停占25.1%，肝脏脂肪增加68.1%，肝脏硬度增加17.4%，而高血压或隐性高血压占19.0%。这些疾病在男性中更为常见，并且随着BMI和年龄的增加而增加。除了高血压,我们在参考组中发现的病例很少。该筛查计划在一大群人中发现了未诊断的肥胖相关疾病。转诊的不均匀分布表明我们需要一种定制的方法来包括更多的肥胖男性。
■769名BMI>30kg/m2且年龄18-60岁的人进行了糖尿病筛查（通过糖化血红蛋白和HbA1c43-48mmol/mol的口服葡萄糖耐量试验进行评估），睡眠呼吸暂停（通过问卷调查筛查，并通过心肺监测评估睡眠障碍的迹象），肝脂肪变性或肝纤维化（通过生物化学和纤维扫描评估）和动脉高血压（通过办公室和24小时血压测量评估）。建立了BMI为18.5-29.9kg/m2的参考人群。
■在提到的那些中，73.0%是女性。我们发现了4.2%的新糖尿病，糖尿病前期占9.1%，25.1％的中度至重度睡眠呼吸暂停，增加肝脏脂肪和增加肝脏硬度68.1％和17.4％，分别,而高血压或隐性高血压占19.0%。男性的疾病患病率更高，并且随着BMI的增加而增加。除了高血压,在参照组中,我们发现少数参与者患有未确诊的疾病.
■基于算法的筛查程序是可行的，并且在很大一部分参与者中揭示了未诊断的肥胖相关疾病。不成比例的转诊模式需要一种量身定制的方法，旨在包括更多的肥胖男性。
■非肥胖组由丹麦南部地区科学伦理委员会批准（项目识别号：S-20210091），该研究发表在clinicaltrials.gov（NCT05176132）。
肥胖的人数正在上升,他们患各种疾病的风险更高。我们测试了一项针对BMI超过30kg/m2的人群的筛查计划，并介绍了与肥胖相关的疾病的患病率。我们筛查了769名年龄在18至60岁、BMI超过30kg/m2的糖尿病患者（生物化学和葡萄糖耐量试验），睡眠呼吸暂停（问卷调查和家庭监测），肝病（生物化学和肝脏扫描）和高血压（办公室和24小时读数）。我们还测试了BMI为18.5-30kg/m2的参考人群。在那些被筛选的人中，73.0%是女性。我们发现4.2%的新糖尿病病例，糖尿病前期占9.1%，睡眠呼吸暂停占25.1%，肝脏脂肪增加68.1%，肝脏硬度增加17.4%，而高血压或隐性高血压占19.0%。这些疾病在男性中更为常见，并且随着BMI和年龄的增加而增加。除了高血压,我们在参考组中发现的病例很少。该筛查计划在一大群人中发现了未诊断的肥胖相关疾病。转诊的不均匀分布表明我们需要一种定制的方法来包括更多的肥胖男性。
