PDF(Pubmed)
Abstract：
Corneal calcification typically progresses slowly but can occasionally advance rapidly. This report details severe stromal calcification following repeat Descemet\'s stripping automated endothelial keratoplasty (DSAEK) in a 75-year-old patient with diabetes, hypertension, and prior ocular surgeries, including cataract surgery, intraocular lens extraction with suturing, and trabeculectomy. Persistent epithelial defects after the surgery led to rapid central stromal calcification within four weeks, significantly reducing visual acuity. Management included switching from betamethasone sodium phosphate to fluorometholone, facilitating complete epithelial recovery within two months. However, persistent stromal opacity necessitated a subsequent penetrating keratoplasty. Infrared absorption spectrophotometry identified calcium phosphate as the primary component of the calcification. This case highlights the importance of vigilant monitoring and proactive management of epithelial defects to prevent rapid calcification following endothelial keratoplasty.
摘要：
角膜钙化通常进展缓慢，但偶尔会快速进展。本报告详述了一名75岁糖尿病患者在重复Descemet剥离自动内皮移植术（DSAEK）后的严重基质钙化，高血压,和之前的眼部手术，包括白内障手术,缝合人工晶状体摘除，和小梁切除术.手术后持续的上皮缺损导致四周内中央基质快速钙化，显著降低视力。管理包括从倍他米松磷酸钠转换为氟米龙，促进上皮在两个月内完全恢复。然而,持续的基质混浊需要随后的穿透性角膜移植术。红外吸收分光光度法确定磷酸钙是钙化的主要成分。此病例强调了警惕监测和积极管理上皮缺损以防止内皮角膜移植术后快速钙化的重要性。
