PDF(Pubmed)
Abstract：
Periodontal disease, a significant worldwide health burden, is characterized by chronic inflammation and destruction of periodontal tissues, including the cementum, periodontal ligament (PDL), alveolar bone, and gingival tissue. Recent research has linked the development and progression of periodontal disease to oxidative stress. This study provides comprehensive explanations of the mechanisms behind oxidative stress in periodontal disease, with a focus on the generation of reactive oxygen species (ROS) and their effects on periodontal tissues. Oxidative stress triggers a number of detrimental reactions, including lipid peroxidation, protein oxidation, and damage to deoxyribonucleic acid (DNA). Alveolar bone resorption, connective tissue degradation, and periodontal inflammation are further conditions exacerbated by these processes. In addition, the delicate balance between antioxidants and oxidants is upset by oxidative stress, which impairs antioxidant defense systems and exacerbates periodontal tissue damage. This review highlights the negative effects of oxidative stress and enhances periodontal health outcomes.
摘要：
牙周病,一个巨大的全球健康负担，以慢性炎症和牙周组织破坏为特征，包括牙骨质,牙周膜（PDL），牙槽骨,和牙龈组织.最近的研究将牙周病的发展和进展与氧化应激联系起来。本研究为牙周病氧化应激背后的机制提供了全面的解释。重点研究了活性氧（ROS）的产生及其对牙周组织的影响。氧化应激会引发许多有害反应，包括脂质过氧化,蛋白质氧化，和脱氧核糖核酸（DNA）的损伤。牙槽骨吸收，结缔组织降解，和牙周炎症进一步加剧了这些过程。此外,抗氧化剂和氧化剂之间的微妙平衡被氧化应激破坏，这损害了抗氧化防御系统并加剧了牙周组织的损伤。这篇综述强调了氧化应激的负面影响，并增强了牙周健康结果。
