PDF(Pubmed)
Abstract：
The development of Hodgkin\'s lymphoma (HL) is a known complication in patients with human immunodeficiency virus (HIV) infection. Extranodal involvement, specifically primary bone marrow Hodgkin\'s lymphoma (PBMHL) is a rare manifestation that has been reported in HIV-positive patients and may represent a distinct entity from HIV-associated HL. We present a case of PBMHL presenting with hemophagocytic lymphohistiocytosis (HLH) in an HIV-positive patient. The 55-year-old male with HIV/AIDS presented with abdominal pain, diarrhea, and fever, leading to hospital admission. Despite initial treatment, he deteriorated, prompting re-admission and investigation revealing pancytopenia and elevated inflammatory markers, suggestive of HLH. Subsequent bone marrow biopsy unexpectedly revealed PBMHL. Treatment with HLH-directed therapy and the HLH-94 protocol resulted in significant clinical improvement. This case underscores the importance of recognizing atypical lymphoproliferative presentations in HIV/AIDS patients and the need for interdisciplinary collaboration in complex cases.
摘要：
霍奇金淋巴瘤（HL）的发展是人类免疫缺陷病毒（HIV）感染患者的已知并发症。结外受累,特别是原发性骨髓霍奇金淋巴瘤(PBMHL)是一种罕见的表现,已在HIV阳性患者中报道,可能代表与HIV相关HL不同的实体.我们介绍了一例HIV阳性患者中存在噬血细胞性淋巴组织细胞增生症（HLH）的PBMHL病例。这名55岁的男性艾滋病毒/艾滋病患者出现腹痛，腹泻,发烧，导致入院。尽管最初的治疗,他恶化了，提示再次入院和调查显示全血细胞减少和炎症标志物升高，暗示HLH。随后的骨髓活检意外显示PBMHL。用HLH定向疗法和HLH-94方案治疗导致显著的临床改善。该病例强调了在HIV/AIDS患者中识别非典型淋巴增生表现的重要性，以及在复杂病例中进行跨学科合作的必要性。
