PDF(Pubmed)
Abstract：
Sertraline hydrochloride belongs to the selective serotonin reuptake inhibitor class of antidepressants, which can cause respiratory depression, hypotension, malignant vomiting, liver function impairment, and other symptoms when taken in excess. To our knowledge, reports of sertraline hydrochloride overdose causing diabetes insipidus in patients are rare. This report describes a unique case of a 17-year-old female patient who developed diabetes insipidus after a one-time oral intake of 20 sertraline hydrochloride tablets (50 mg/tablet) during the later course of treatment. Her symptoms were effectively relieved after treatment with pituitrin.
摘要：
盐酸舍曲林属于选择性5-羟色胺再摄取抑制剂类抗抑郁药，会导致呼吸抑制，低血压,恶性呕吐,肝功能损害，以及其他过量服用时的症状。据我们所知,盐酸舍曲林过量导致患者尿崩症的报告很少见。本报告描述了一个17岁女性患者的独特病例，该患者在后期治疗过程中一次性口服20片盐酸舍曲林片（50mg/片）后出现尿崩症。经垂体后叶素治疗后，患者症状得到有效缓解。
