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Abstract：
Background Oral squamous cell carcinoma (OSCC) is the most common type of head-neck cancer. The staging and grading of OSCC play an important role in disease management. Accurate staging helps in patient counseling, treatment planning, and prognostication in head-neck SCC. However, discrepancies between pathological and clinical staging have been stated, which affect disease prognosis. Method A retrospective review of 60 surgically treated patients with OSCC was done. Tumor-nodal-metastasis staging, both clinically and pathologically, was equated and tabulated to determine upstaging, downstaging, and cases where no stage change occurred. Additionally, the clinical and pathological TNM (tumor, node, metastasis) staging were correlated with the evaluation of histopathological grading. Results This study comprised 60 surgically operated OSCC patients. The T and N stages showed significant differences when compared clinically and pathologically. There was no significant correlation between histopathological grading and the disparities in TNM staging. Conclusion Some discrepancies exist between TNM staging evaluated clinically and pathologically for OSCC, which may show its effect on treatment planning and the prognosis of affected individuals. The histopathological analysis is the gold standard for the categorization of staging and grading in OSCC for proper treatment planning.
摘要：
背景技术口腔鳞状细胞癌(OSCC)是头颈部肿瘤的最常见类型。OSCC的分期和分级在疾病管理中起着重要作用。准确的分期有助于患者咨询，治疗计划,和头颈部SCC的预后。然而,已经说明了病理分期和临床分期之间的差异，影响疾病预后。方法对60例经手术治疗的OSCC患者进行回顾性分析。肿瘤淋巴结转移分期，在临床和病理上，被等同和制表以确定升级，降级，以及没有发生阶段变化的情况。此外,临床和病理TNM(肿瘤，节点,转移）分期与组织病理学分级的评估相关。结果本研究包括60例手术操作的OSCC患者。在临床和病理上比较时，T和N分期显示出显着差异。组织病理学分级与TNM分期差异之间没有显着相关性。结论OSCC的TNM分期在临床和病理上存在一定的差异,这可能显示其对受影响个体的治疗计划和预后的影响。组织病理学分析是OSCC中分期和分级分类以进行适当治疗计划的金标准。
