Abstract：
Chlorogenic acid (CHA) is a phenolic substance found in various edible plants, such as tea and green coffee extracts. This chemical has demonstrated significant efficacy in reducing the probability of many diseases in preclinical and clinical environments. Chlorogenic acid (CHA) possesses several pharmacological attributes, such as anticancer, hepatoprotective, antimicrobial, immune-suppressant, antioxidant, and antidiabetic activities. Its applications extend to multiple industries, such as food, chemicals, medicine, and healthcare. Studies have shown that CHA can exert its anticancer effects through numerous mechanisms. It can hinder the process of cell division, trigger cell apoptosis, and suppress an increase in cancerous cell growth. The literature research conducted for this study revealed a variety of molecular and cellular processes influencing distinct signaling pathways. These mechanisms include angiogenesis, invasion and migration, oxidative stress, inflammation, cell cycle arrest, and proliferation.However, significant issues surround the use of CHA, primarily due to its limited bioavailability in animal models. This review focuses on the chemistry, natural sources, pharmacokinetics, and underlying mechanisms of action of CHA and its clinical utility in treating life-threatening diseases, such as cancer. The manuscript provides insight into novel formulation approaches.
摘要：
绿原酸（CHA）是在各种食用植物中发现的酚类物质，如茶和绿茶提取物。这种化学物质在降低临床前和临床环境中许多疾病的可能性方面表现出显著的功效。绿原酸（CHA）具有几种药理属性，比如抗癌，保肝,抗菌，免疫抑制剂,抗氧化剂，和抗糖尿病活性。它的应用扩展到多个行业，比如食物，化学品,医学,和医疗保健。研究表明，CHA可以通过多种机制发挥其抗癌作用。它可以阻碍细胞分裂的过程，触发细胞凋亡，并抑制癌细胞生长的增加。为这项研究进行的文献研究揭示了各种影响不同信号传导途径的分子和细胞过程。这些机制包括血管生成，入侵和迁移，氧化应激，炎症,细胞周期停滞,和扩散。然而,围绕CHA的使用存在重大问题，主要是由于其在动物模型中的生物利用度有限。这篇综述侧重于化学，自然来源,药代动力学，以及CHA的潜在作用机制及其在治疗危及生命的疾病中的临床效用，比如癌症。该手稿提供了对新颖配方方法的见解。
