METHODS: Here, we present two cases of effective use of hpCBD in both refractory and super- refractory status epilepticus. The administration of the nasogastric tube permitted the resolution of status epilepticus without adverse events. At 6-month follow-up, both patients were on hpCBD treatment, which continued to be efficacious for treating seizures.
CONCLUSIONS: According to our experience, hpCBD should be taken into consideration as an add-on therapy of RSE and SRSE while also considering the possibility of maintaining this treatment during the follow-up of patients. However, more studies and real-world experiences are needed to better understand its effectiveness in this setting and the interaction with other ASMs.
方法:这里,我们介绍了2例hpCBD在难治性和超难治性癫痫持续状态中的有效应用。鼻胃管的给药可以缓解癫痫持续状态,而没有不良事件。在6个月的随访中,两名患者均接受hpCBD治疗,继续有效治疗癫痫发作。
结论:根据我们的经验,应考虑将hpCBD作为RSE和SRSE的附加疗法,同时还考虑在患者随访期间维持这种治疗的可能性。然而,需要更多的研究和现实世界的经验,以更好地了解其在这种情况下的有效性以及与其他ASM的相互作用。