Abstract：
BACKGROUND: Refractory and super-refractory status epilepticus are medical emergencies that must be promptly treated in consideration of their high mortality and morbidity rate. Nevertheless, the available evidence of effective treatment of these conditions is scarce. Among novel antiseizure medications (ASMs), highly purified cannabidiol (hpCBD) has shown noteworthy efficacy in reducing seizures in Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and Tuberous Sclerosis Complex (TSC).
METHODS: Here, we present two cases of effective use of hpCBD in both refractory and super- refractory status epilepticus. The administration of the nasogastric tube permitted the resolution of status epilepticus without adverse events. At 6-month follow-up, both patients were on hpCBD treatment, which continued to be efficacious for treating seizures.
CONCLUSIONS: According to our experience, hpCBD should be taken into consideration as an add-on therapy of RSE and SRSE while also considering the possibility of maintaining this treatment during the follow-up of patients. However, more studies and real-world experiences are needed to better understand its effectiveness in this setting and the interaction with other ASMs.
METHODS: Here, we present two cases of effective use of hpCBD in both refractory and super- refractory status epilepticus. The administration of the nasogastric tube permitted the resolution of status epilepticus without adverse events. At 6-month follow-up, both patients were on hpCBD treatment, which continued to be efficacious for treating seizures.
CONCLUSIONS: According to our experience, hpCBD should be taken into consideration as an add-on therapy of RSE and SRSE while also considering the possibility of maintaining this treatment during the follow-up of patients. However, more studies and real-world experiences are needed to better understand its effectiveness in this setting and the interaction with other ASMs.
摘要：
背景：难治性和超难治性癫痫持续状态是医疗紧急情况，考虑到其高死亡率和发病率，必须及时治疗。然而，有效治疗这些疾病的现有证据很少。在新型抗癫痫药物(ASM)中，高纯度大麻二酚（hpCBD）在减少Lennox-Gastaut综合征（LGS）的癫痫发作方面显示出值得注意的功效，德拉韦综合征（DS），结节性硬化症（TSC）。
方法：这里，我们介绍了2例hpCBD在难治性和超难治性癫痫持续状态中的有效应用。鼻胃管的给药可以缓解癫痫持续状态，而没有不良事件。在6个月的随访中，两名患者均接受hpCBD治疗，继续有效治疗癫痫发作。
结论：根据我们的经验，应考虑将hpCBD作为RSE和SRSE的附加疗法，同时还考虑在患者随访期间维持这种治疗的可能性。然而,需要更多的研究和现实世界的经验，以更好地了解其在这种情况下的有效性以及与其他ASM的相互作用。
方法：这里，我们介绍了2例hpCBD在难治性和超难治性癫痫持续状态中的有效应用。鼻胃管的给药可以缓解癫痫持续状态，而没有不良事件。在6个月的随访中，两名患者均接受hpCBD治疗，继续有效治疗癫痫发作。
结论：根据我们的经验，应考虑将hpCBD作为RSE和SRSE的附加疗法，同时还考虑在患者随访期间维持这种治疗的可能性。然而,需要更多的研究和现实世界的经验，以更好地了解其在这种情况下的有效性以及与其他ASM的相互作用。
