Abstract：
UNASSIGNED: Endometrial hyperplasia (EH), an abnormal proliferation of the endometrial cells, is considered as one of the most common causes of abnormal uterine bleeding. Previous studies have reported that melatonin plays a fundamental role in disease treatment. This study aimed the comparison of the effects of progesterone, as the most common therapeutic approach, and melatonin with progesterone alone in improvement of non-atypical endometrial hyperplasia (NEH) and changes in pro-inflammatory cytokine levels.
UNASSIGNED: Study population consisted of 40 patients with NEH. Patients were divided into two groups, including 20 subjects treated with melatonin and progesterone and 20 individuals treated with progesterone alone. The blood and endometrial sampling was performed from participants before and after a three-month treatment. The histological examination was microscopically done. The serum levels of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) were measured using ELISA.
UNASSIGNED: There was no significant difference in the diabetes status and mean age between patients treated with progesterone and melatonin and those treated with progesterone alone. The improvement rate in the EH was significantly higher in individuals treated with progesterone and melatonin than those treated with progesterone alone (p < 0.05). Additionally, the patients treated with progesterone and melatonin showed significant increases inIFN-γ and TNF-αlevels compared to the control group (p < 0.001-P < 0.05).
UNASSIGNED: Melatonin supplementation has a beneficial effect in the treatment of EH due perhaps to enhance the level of IFN-γ and TNF-α.
UNASSIGNED: Study population consisted of 40 patients with NEH. Patients were divided into two groups, including 20 subjects treated with melatonin and progesterone and 20 individuals treated with progesterone alone. The blood and endometrial sampling was performed from participants before and after a three-month treatment. The histological examination was microscopically done. The serum levels of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) were measured using ELISA.
UNASSIGNED: There was no significant difference in the diabetes status and mean age between patients treated with progesterone and melatonin and those treated with progesterone alone. The improvement rate in the EH was significantly higher in individuals treated with progesterone and melatonin than those treated with progesterone alone (p < 0.05). Additionally, the patients treated with progesterone and melatonin showed significant increases inIFN-γ and TNF-αlevels compared to the control group (p < 0.001-P < 0.05).
UNASSIGNED: Melatonin supplementation has a beneficial effect in the treatment of EH due perhaps to enhance the level of IFN-γ and TNF-α.
摘要：
■子宫内膜增生（EH），子宫内膜细胞的异常增殖，被认为是异常子宫出血的最常见原因之一。先前的研究报道，褪黑激素在疾病治疗中起着基本作用。这项研究旨在比较黄体酮的影响，作为最常见的治疗方法，褪黑素和孕激素单独用于改善非非典型子宫内膜增生（NEH）和促炎细胞因子水平的变化。
■研究人群包括40名NEH患者。患者分为两组，包括20名接受褪黑激素和孕酮治疗的受试者和20名单独接受孕酮治疗的受试者。在三个月的治疗前后对参与者进行血液和子宫内膜采样。在显微镜下进行组织学检查。采用ELISA法测定血清肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)水平。
■使用孕酮和褪黑素治疗的患者与单独使用孕酮治疗的患者之间的糖尿病状态和平均年龄没有显着差异。用孕酮和褪黑素治疗的个体的EH改善率明显高于单用孕酮治疗的个体(p<0.05)。此外,与对照组相比，接受孕酮和褪黑素治疗的患者的IFN-γ和TNF-α水平显着升高（p<0.001-P<0.05）。
■补充褪黑素在EH的治疗中具有有益效果,这可能是由于提高了IFN-γ和TNF-α的水平。
■研究人群包括40名NEH患者。患者分为两组，包括20名接受褪黑激素和孕酮治疗的受试者和20名单独接受孕酮治疗的受试者。在三个月的治疗前后对参与者进行血液和子宫内膜采样。在显微镜下进行组织学检查。采用ELISA法测定血清肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)水平。
■使用孕酮和褪黑素治疗的患者与单独使用孕酮治疗的患者之间的糖尿病状态和平均年龄没有显着差异。用孕酮和褪黑素治疗的个体的EH改善率明显高于单用孕酮治疗的个体(p<0.05)。此外,与对照组相比，接受孕酮和褪黑素治疗的患者的IFN-γ和TNF-α水平显着升高（p<0.001-P<0.05）。
■补充褪黑素在EH的治疗中具有有益效果,这可能是由于提高了IFN-γ和TNF-α的水平。
